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A FASTer and Cleaner Alternative to ‘Dilute and Shoot’

UCT, Inc.
12 Jan 2015

The increased volume in recent years of confirmatory tests in urine toxicology by LC/MS/MS has led to alternatives to traditional sample preparation techniques. The usual liquid/liquid or solid phase extraction with concentration has given way to ‘dilute and shoot’ of urine samples. This poster shows how the FASt method addresses shortcomings of this method by applying a lowered urine sample dilution (as low as 1:1) to the specially designed cartridge.

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Clean Screen® FASt Columns

UCT, Inc.

The Clean Screen® FASt column is a novel approach to improved sample preparation for LC/MS analysis. The column employs a one step process to prepare urine samples for analysis of multiple drugs and metabolites. By quickly and efficiently reducing the amount of unwanted matrix and particulates in the final sample, the analysis can proceed with less chance of matrix suppression and LC column clogging.

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Clean Screen® FASt THC

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CLEAN SCREEN FASt THC is the newest sorbent in our FASt product lineup. It employs a process that uses positive pressure and a solid phase sorbent bed built with small pore frits to quickly and efficiently prepare urine samples for LC/MS analysis. This method eliminates timely centrifugation, reduces matrix suppression effects, and removes particulates greater than ~1μm. Samples can be diluted at a ratio as low as 1:1, which is useful for analytes at very low concentrations.

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Clean Screen® FASt Well Plate

UCT, Inc.

The FASt Well Plate is a novel approach to improved sample preparation for LC/MS analysis. The well plate employs a one step process to prepare urine samples for analysis of multiple drugs and metabolites. By quickly and efficiently reducing the amount of unwanted matrix and particulates in the final sample, the analysis can proceed with less chance of matrix suppression and LC column clogging.

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Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Labware and Lab SuppliesLabware and lab supplies include various forms of glassware, plasticware, reagents and personal protective equipment (PPE) and are used across all scientific laboratories, enabling daily tasks to be performed. Explore a range of flasks and beakers, petri dishes, carboys and storage bottles. Labware such as condensers, desiccators and burettes are also available for more specific tasks. Find the best labware and lab supplies in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Toxicology / Drugs of Abuse TestingToxicology and Drugs of Abuse Testing is the investigation into toxic and illegal substances found at the scene of a crime or from a suspect and / or victim associated with a scene of a crime. Analyzers, immunoassays and drugs of abuse test kits and presumptive test kits are an essential aspect of toxicology investigation.UrineThe analysis of urine is important in medicinal, anti-doping, forensic and life sciences applications. The ability to evaluate what someone has ingested through their urine enables fast detection and diagnosis of certain illnesses.

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