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A Comparative Study of Affibody, Panitumumab and EGF for Near-Infrared Fluorescence Imaging of EGFR- and EGFRvIII-Expressing Tumors

LICORbio
7 Oct 2013

Aberrant overexpression and/or activation of epidermal growth factor receptor (EGFR) is associated with many types of cancers. While EGFR has been extensively studied as a molecular imaging target, information about the common in-frame deletion mutant, EGFRvIII (targeting) is lacking. This poster describes a comparative study using labeled tumor imaging agents; EGFR-specific affibody, therapeutic antibody panitumumab, and ligand EGF, for the detection of EGFR- and EGFRvIII-expressing Tumors.

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In Vivo Imaging Systems<i>In vivo</i> imaging systems, including pre-clinical imaging systems and medical imaging systems are used to non-invasively visualize and capture images of live animals and plants. Monitor the natural processes or diseases of your subjects using small-animal pre-clinical imaging systems, including single photon positron emission tomography (SPECT), positron emission tomography (PET), computed tomography (micro-CT), magnetic resonance imaging (MRI), X-ray radiography, ultrasound, fluorescence and bioluminescence imagers. Multimodal systems and software solutions are also available for correlative analysis of organ, tissue, cell, or molecular-level processes. Find the best in vivo imaging products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.TumorsTumor research focuses on understanding abnormal cell growth that leads to cancer. Identifying biomarkers, studying tumor microenvironments, and developing targeted therapies are critical for advancing cancer treatment. Early detection and personalized treatment options are key to improving outcomes for patients. Browse our peer-reviewed product directory to explore tools for tumor research, diagnostics, and cancer therapies; compare products, read customer reviews, and get pricing directly from manufacturers.Cell AnalysisThe analysis of cells allows researchers to understand the factors which contribute to cell health and function. These influencing processes can then be predicted and altered, leading to the development of medication and disease treatments.Cancer ResearchAlthough cancer is often referred to as a single condition, it actually consists of more than 100 different diseases. Microscopy, mass spectrometry, high throughput sequencing and flow cytometry are some of the most common techniques employed in cancer research labs.ImagingImaging techniques are essential for obtaining visual representations of samples to understand structures, processes, and function in biological, chemical, and physical research. These tools range from traditional light microscopy to advanced imaging modalities like MRI and electron microscopy, providing researchers with valuable data for diagnostics, drug discovery, and material analysis. Explore imaging solutions in our peer-reviewed product directory to compare products, check reviews, and get pricing directly from manufacturers.EGFR

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A Comparative Study of Affibody, Panitumumab and EGF for Near-Infrared Fluorescence Imaging of EGFR- and EGFRvIII-Expressing Tumors