ResourceLife Sciences
A 3D Co-Culture Model-Based Assay to Assess Liver Kupffer-Cell Activation and Functionality
27 Mar 2013At the SOT conference in San Antonio Pfizer’s Drug Safety R&D department and InSphero presented poster presentation with results that highlight the potential of our 3D InSight™ Rat Liver Microtissues for evaluating Kupffer-cell mediated liver toxicity. A unique advantage of this model is the ability to do histological assessment of the microtissues to assess pathological changes (which is a sensitive visual end-point for assessing drug induced liver injury).
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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.ToxicityToxicity is defined as the degree to which a substance can harm humans or animals. It is essential to study the toxicity of pharmaceutical products during the development process so that optimum dosage can be established for the administration of the drug.Drug DevelopmentDrug development refers to the process of bringing a new drug to market.