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2 Ways to Attain Sharper Peak Shape and Higher Sensitivity in Gas Chromatography

Phenomenex Inc
10 Apr 2016

In gas chromatography the Method Detection Limit, or MDL, is the minimum concentration of a substance that can be measured with 99% confidence that the analyte concentration is greater than zero. It can be difficult for GC analysts to find a method sensitive enough to meet the MDLs, this technical note from Phenomenex addresses that issue by discussing two methods which produce a sharper peak shape and have higher sensitivity.

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Zebron ZB-35 GC Columns

Phenomenex Inc

Low Bleed, Intermediate Polarity Selectivity for GC/MSIntermediate polarity column for high molecular weight analysisInert to minimize analyte adsorption, improve efficiency, and reproducibilityMore rugged (longer column life) than other polar phasesExcellent for trace analysis with bleed-sensitive detectors (MS, FID, ECD, NPD)Recommended UseAmines, Aroclors, Drugs, EPA Methods (508, 608, 8081, 8141, 8151), Pesticides, Pharmaceuticals, Semi-volatiles, Steroids

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Zebron ZB-1ms GC Columns

Phenomenex Inc

Low Bleed Performance for GC/MSVery low bleed (MS Certified) especially suited to high sensitivity GC/MSImproved signal-to-noise ratio for better sensitivity and mass spectral integrityExtremely inert for active compounds such as drugs, pesticides, acids, and basesLower Overall Column ActivityActivity is a key measure of column quality. ZB-1ms columns are aggressively tested to ensure full deactivation.Recommended ApplicationsAcids, Amines, Diesel Fuel, Drugs, Flavors & Fragrances, PCBs (EPA Method 1668)

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Zebron™ ZB-5ms GC Columns

Phenomenex Inc

Low Bleed Performance for GC/MSMost popular starting column for method developersArylene Matrix Technology (AMT) provides a highly stable arylene phase for enhanced resolution of PAHs and multi-ring aromatic compoundsLow bleed (MS certified) especially suited to high sensitivity work using GC/MSRecommended UseAcids, Alkaloids, Amines, Dioxins, Drugs, EPA Methods (525, 610, 625, 8100), Essential Oils/Flavors, FAMEs, Halo-hydrocarbons, PCBs/Aroclors, Pesticides/Herbicides, Phenols, Residual Solvents, Semi-volatiles, Solvent Impurities

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AutosamplersAutosamplers are automated sample loaders used with a number of separation and analytical techniques. HPLC autosamplers use automated partial or full-loop injection systems and place samples in vials or microplates for analysis. Autosamplers can also be used for elemental analysis. Features to consider include repeatability, syringe capacity, footprint and temperature controls.  Gas ChromatographyGas chromatography (GC) is an analytical technique used to separate and quantitate mixtures of small and volatile compounds. Gas chromatographs or GC systems include components such as GC columns, detectors, pumps and autosamplers. Choose from packed or capillary GC columns, flame ionization (FID), photoionization (PID) electron capture detectors and selective or non-selective detectors. 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2 Ways to Attain Sharper Peak Shape and Higher Sensitivity in Gas Chromatography