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GPCR ligand binding with Tag-lite technology

Cisbio Bioassays

Cisbio Bioassays offer a comprehensive cellular platform to develop HTRF® ligand binding assays.Features: • Single technology and cellular platform for all GPCR assays • Unique non-radioactive ligand binding assays • Miniaturization down to < 10µl • Peptidic and non-peptidic fluorescent ligands • High Specific Binding • Low Non-Specific Binding with HTRF technology Tag-lite fluorescent ligands available for (Feb10): Vasopre…

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(RS)-3,5-DHPG

Tocris Bioscience.

Chemical Name: (RS)-3,5-Dihydroxyphenylglycine Selective group I metabotropic glutamate receptor agonist which activates both mGlu1 and mGlu5. Also reported to be an antagonist at metabotropic glutamate receptors linked to phospholipase D. Selective group I mGlu agonist.

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FasL-Strep Apoptosis Assays

IBA BioTAGnology

FasL-Strep, a stable homotrimer, efficiently induces the CD95 pathway of apoptosis and is highly suited for evaluation of CD95 (Fas) receptor-ligand interaction. Human or murine FasL-Strep (CD95L-T4) is an engineered human or murine Fas (CD95) ligand. C-terminal fusion of the T4-FOLDON to the extracellular FasL (CD95L) receptor-binding domain (E142-L281) results in bioactive, conformationally stabilized, well defined trimers…

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Agilent Drug Discovery Services: HTS

Agilent’s contract Lead Discovery Service utilizes label-free RapidFire technology for direct quantitation of a wide range of native analytes across diverse therapeutic areas. Supports SAR programs via retesting of hits. Uses your existing assays or RapidFire custom-developed assays. Quick data turnaround for faster drug discovery decisions.Screened as singletons or compressed format The ideal candidate assays are often the sa…

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Ion Channel Cell-Based Assays

ChanTest Corporation

Functional cell-based assays provide more physiologically useful information compared to binding and non-cellular assays. ChanTest offers cell-based assays to over 90 ion channel targets for screening and profiling for both early discovery and safety liability assessment. Both replicating and division-arrested cell lines are available for most targets which have been validated on a variety of automated electrophysiology plat…

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Mass Flow Controllers & Mass Flow Meters

MKS Instruments Inc.

Mass Flow Controllers & Mass Flow Meters - Mass Flow Controller Products from MKS Instruments Enabling our customers to bring their products and processes to market faster, more reliably, and more cost effectively is at the heart of our mass flow controller (MFC) design philosophy. The MKS family of mass flow controller and mass flow meter instruments measure and control the flow of critical gases in a wide variety of applicat…

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Membrane Preparation

CCS Cell Culture Service GmbH

Cell Membranes - Custom Preparation of Cell Membranes from CCS Cell Culture Service Preparations membranes from cell which are expressing a target receptor, transporter or ion channel at a high density are a useful tool in drug research. Embedded in a membrane fragment or vesicle the proteins remain in a functional native confirmation. Ligand binding assay and functional GTP-gammaS assays can be performed with these preparati…

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