SU5416​
STEMCELL Technologies Inc.Tyrosine kinase inhibitor; Inhibits of KDR, PDGFR, KIT, RET, FLT-3, ABL and ALK
Tyrosine kinase inhibitor; Inhibits of KDR, PDGFR, KIT, RET, FLT-3, ABL and ALK
Cyclin/CDK pathway inhibitor; Inhibits CDK1 and CDK2
Tryosine kinase inhibitor and epigenetic modifier; Inhibits PDGF, FGF, EGF, TGFß, SIRT1, and SIRT5
Non-muscle myosin II (NM II) ATPase inhibitor
Ubiquitin-proteasome inhibitor; NF-kB pathway inhibitor; I?B activator
PI3K/AKT pathway inhibitor; Inhibits COX-1 and COX-2
Inhibits glycogen synthase kinase 3ß (GSK3ß)
Prostanoid pathway activator; Inhibits 15-hydroxy PGDH
Epigenetic modifier; Inhibits histone EZH2 lysine methyltransferase
Activates nuclear factor erythroid 2-related factor 2 (Nrf2) protein
Activin/NODAL/TGF-ß pathway inhibitor; Inhibits ALK5, ALK4, and ALK7
Tyrosine kinase inhibitor; Inhibits EGFR, HER2, JAK2, JAK3 and STAT5a/b
Epigenetic modifier; Inhibits SIRT2 histone deacetylase
PI3K/AKT pathway inhibitor; Inhibits AKT1, AKT2, AKT3
PI3K/AKT pathway inhibitor; Inhibits AKT
Retinoid pathway activator; Activates retinioc acid receptor (RAR) alpha
Epigenetic modifier; Inhibits histone acetyltransferase (HAT)
MEK/ERK pathway inhibitor; Inhibits B-RAF, B-RAFV600E and C-RAF-1
MEK/ERK pathway inhibitor; Inhibits MEK1 and MEK2
Inhibits autophagy and vacuolar H+-ATPase (V-ATPase)