High-Throughput Screening Products & Reviews

Agilent’s contract Lead Discovery Service utilizes label-free RapidFire technology for direct quantitation of a wide range of native analytes across diverse therapeutic areas. Supports SAR programs via retesting of hits. Uses your existing assays or RapidFire custom-developed assays. Quick data turnaround for faster drug discovery decisions.Screened as singletons or compressed format The ideal candidate assays are often the sa…

CYTOOplates are optical grade, glass-bottom microplates in 96 or 384-well format with black-side upper structures for fluorescence applications offering reduced background and minimum scattered light. Each well holds an array of over 4,000 (96-well) or 1,000 (384-well) identical micropatterns. CYTOOplates are compatible with your High Content Screening equipment.

A highly modular robotic platform that enables higher throughput, automated workflows in chemicals and energy, pharmaceutical and biotechnology, and consumer and industrial product laboratories. The Core Module platform empowers every step in the experimentation lifecycle. Ease of modularity of the numerous Deck Elements and Arm Effector options, allows definition of optimal configuration to satisfy changing laboratory needs a…

Evaluate compounds in human stem cell-derived, ventricular-type cardiomyocytes. Effects on action potential parameters are evaluated in single human cardiomyocytes using patch-clamp recording Benefits: Human ion channels expressed in a native cardiac environment Detects AP Prolongation (QT risk) and EADs (Torsade trigger) Stable recordings at physiological temperature with minimal diffusion delays Cost-effective Ra…

Functional cell-based assays provide more physiologically useful information compared to binding and non-cellular assays. ChanTest offers cell-based assays to over 90 ion channel targets for screening and profiling for both early discovery and safety liability assessment. Both replicating and division-arrested cell lines are available for most targets which have been validated on a variety of automated electrophysiology plat…

  ChemBridge Fragment Library compounds for fragment-based drug discovery and screening.  

GPCR Cell Lines - Validated Cell Lines for High-Throughput-Screening In cooperation with Cisbio Bioassays CCS has developed a set of recombinant cell lines stably expressing G-Protein coupled recptors (GPCRs) of high pharmacological relevance. The cell lines have been generated by stable transfection of CHO-K1 cells and subsequent clonal selection. They have been specifically validated for a read-out in homogenous time-resolv…

Cell Membranes - Custom Preparation of Cell Membranes from CCS Cell Culture Service Preparations membranes from cell which are expressing a target receptor, transporter or ion channel at a high density are a useful tool in drug research. Embedded in a membrane fragment or vesicle the proteins remain in a functional native confirmation. Ligand binding assay and functional GTP-gammaS assays can be performed with these preparati…

SCOPE, Structure-based compound optimization prioritization and evolution is an innovation from VLife to overcome challenges in lead optimization. SCOPE provides the user a way to address known problems like poor correlation between energy and activity, insensitive docking scoring functions for molecule prioritization and insufficient clues in ligand design for improvement in activity. SCOPE smartly understands the information…

Human Cav2.2/β3/α2δ calcium ion channel-expressing, stable replicating cell line (CHO-K1). Cat#: CT6159. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: PatchXpress® , QPatch HT™ , FLIPR®

Human Nav1.8/b3 sodium ion channel-expressing, stable replicating cell line (CHO-K1). Cat#: CT6011. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: PatchXpress® , QPatch HT™ , IonWorks Quattro®

Human a3/β4 Nicotinic Acetylcholine Receptor-expressing, stable replicating cell line (CHO-K1). Cat#: CT6021. Cryopreserved cells, 6x10E6 cells/vial. Platform validation: QPatch HT™

Human GABAA (α5β2γ2) Receptor-expressing, stable replicating cell line (CHO-K1). Cat#: CT6119. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: FLIPR®

Human GABAA (a5β2γ2) Receptor-expressing, stable replicating cell line (CHO-K1). Cat#: CT6119. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: FLIPR®

Human Cav2.2/b3/a2d calcium ion channel-expressing, stable replicating cell line (CHO-K1). Cat#: CT6159. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: PatchXpress® , QPatch HT™ , FLIPR®

Human Cav2.1/b4/a2d calcium ion channel-expressing, stable replicating cell line (CHO-K1). Cat#: CT6196. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: PatchXpress® , QPatch HT™

Human GABAA (α3/β2/γ2) Receptor-expressing, transiently transfected cells (HEK293). Cat#: CT7022. Cryopreserved cells, 6x10E6 cells/vial. Platform validation: PatchXpress®, FLIPR®

Human a7 Nicotinic Acetylcholine Receptor-expressing, stable replicating cell line (CHO-K1). Cat#: CT6201. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: QPatch HT™ , FLIPR®

Human Cav2.1/β4/α2δ calcium ion channel-expressing, stable replicating cell line (CHO-K1). Cat#: CT6196. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: PatchXpress® , QPatch HT™

Human Nav1.8/β3 ion channel-expressing, division-arrested cells (CHO-K1). Cat#: CT4011. Three vials of Cyropreserved irradiated cells, 2x10E6 cells/vial (6x10E6 cells total). Platform validation: PatchXpress®

Human α3/β4 Nicotinic Receptor-expressing, division-arrested cells (CHO-K1). Cat#: CT4021. Cryopreserved irradiated cells, 6 million cells per vial.. Platform validation: FlexStation III

Human GABAA (α5/β2/γ2) ion channel-expressing, division-arrested cells (CHO-K1). Cat#: CT4119. Cryopreserved irradiated cells, 6 million cells per vial.. Platform validation: FlexStation III

Human GABAA (a5/b2/g2) ion channel-expressing, division-arrested cells (CHO-K1). Cat#: CT4119. Cryopreserved irradiated cells, 6 million cells per vial.. Platform validation: FlexStation III

Human Cav2.2/b3/a2d1 ion channel-expressing, division-arrested cells (CHO-K1). Cat#: CT4159. Three vials of Cyropreserved irradiated cells, 2x10E6 cells/vial (6x10E6 cells total). Platform validation: PatchXpress®

Human GABAA (α2β2γ2) Receptor-expressing, stable replicating cell line (CHO-K1). Cat#: CT6118. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: FLIPR®