Enzymes > Enzyme Inhibitors Products & Reviews

thymidylate synthase inhibitor

SB-431542 is a potent and selective inhibitor of activin receptor-like kinase ALK5, the TGF- β1 receptor. 

Mycotoxin contaminant of fruit and cereal products. Exhibits antifungal and phytotoxic activity. Has also been shown to possess DNA strand-breaking activity and inhibits the activity of topoisomerase IIα in mammalian cell models.

MEK/ERK pathway inhibitor; Inhibits MEK1 and MEK2

Activin/Nodal/TGFß pathway inhibitor; Inhibits ALK5

Activin/BMP/TGF-ß pathway inhibitor; Inhibits ALK5

Antioxidant; COX-1 inhibitor

Epigenetic modifier; Inhibits DNA methyltransferase (DNMT)

RHO/ROCK pathway inhibitor; Inhibits ROCK2

cAMP pathway activator; Inhibits type 4 cyclic nucleotide phosphodiesterases (PDE4)

Epigenetic modifier; Inhibits HDAC1 and HDAC3

p38 MAPK inhibitor

p38 MAPK inhibitor

WNT pathway activator; Inhibits GSK3a and GSK3ß

Activin/BMP/TGF-ß pathway inhibitor; Inhibits ALK4, ALK5, and ALK7

NHEJ pathway inhibitor; inhibits DNA ligase IV

Epigenetic modifier; Inhibits DNA methyltransferases (DNMTs)

Epigenetic modifier; Inhibitor of Sir2p, SIRT1, and SIRT2

Activin/NODAL/TGF-ß pathway inhibitor; Inhibits SMAD3

JNK pathway inhibitor; Inhibits JNK1, JNK2 and JNK3

Epigenetic modifier; Inhibitor of Sir2p

JAK/STAT pathway inhibitor; Inhibits STAT5

Calcium signaling inhibitor; Inhibits calcium/calmodulin-dependent kinase kinases (CaMKKs)

HGF pathway inhibitor; Inhibits MET

MEK/ERK pathway inhibitor; Inhibits VEGFR2, FGFR1, and PDGFRB