The iLite® Fc Effector Reporter Gene Bioassays Portfolio offers a variety of reporter gene cell lines and target cells that can be used in MOA-reflective assays to measure the Fc effect of antibodies and other biologics that specifically bind and activate Fc receptors. Using a Luciferase reporter gene system offers a convenient and powerful way of measuring antibodies' in vitro efficacy in triggering ADCC and ADCP.
Svar offers assistance in gene therapy projects through robust platforms suited for all phases of drug development and experience from immunoassasy product development as well as their CRO services. Svar currently offer cell-based assays for Neutralizing antibody assessment and custom-made immunoassays for Total antibody assessment.
Complement biomarker assays target selected biomarkers of high relevance. These assays are important and well-suited for analyses in drug development and academic research. They stand out with very low cross-reactivity and high specificity as they bind neo-epitopes of cleaved products or complexes, where this is relevant.
In diagnosis of Rheumatoid Arthritis (RA), the measurement of anti-CCP is integral. People who test positive for Anti-CCP, are very likely to develop or have already developed RA, but not all who have RA, necessarily develop anti-CCP. Early detection of RA is crucial for reducing tissue damage.
Recombinant antigens and lentivirus for emerging SARS-CoV-2 variants
TaqMan ® SNP Genotyping Assays
Svar CRO Services provides direct value through an extensive toolbox of in-house products, scientific expertise, and end-to-end customizable solutions – everything to ensure the success of your drug development program.
AbZelect™ and AbZelectPRO™ support cell line development (CLD) to rapidly progress therapeutic protein and recombinant vaccine projects while de-risking the journey to Investigational New Drug (IND) application.
EpiScreen® – an extensive suite of bioinformatic and primary human cell-based assays for immunogenicity assessment to inform of potential safety and efficacy risks in the clinic.
The Factor P Functional assay is an ELISA that combines principles of the functional complement activity assays with the use of labeled antibodies specific for deposited complement proteins. The amount of deposited complement proteins is proportional to the functional activity of Properdin in the sample.
The iLite® CDC bioassay is based on a reporter gene and offers a convenient and powerful way of measuring antibodies' efficacy in eliciting complement-dependent cytotoxicity in test samples, including human serum.
Service for toxicology screening, lead identification/ optimization and in vitro model development using organ-on-chip technology by Dynamic42
Hit confirmation service is based on the Cellular Thermal Shift Assay (CETSA) and allows for assessment of compound binding to a selected target protein in its native state without any modifications to the protein or the compound.
Primary screening based on Cellular Thermal Shift Assay (CETSA) allows for rapid identification of high quality chemical starting points against the native, full-length protein in live cells.
Virtual tissues services for biomedical research features high fidelity tissue simulation and modelling to grow virtual tissue from a single cell, giving unprecedented insight into lineage commitment phenomena of stem cells with insight into signalling pathways and detailed gene regulatory networks.With Endogenics complementing traditional techniques, researchers can simulate human cell development and tissue organization and…
Sensitive DNA damage assessment Very low compound requirement Rapid turnaround, ideal for screening Reliable testing by genetic toxicology experts Assay Principles The Comet assay, also called single cell gel electrophoresis, is a technique used for the sensitive detection of DNA damage in individual cells following exposure to a test compound. Electrophoresis is performed on exposed cells that have been embedded i…
Nano BioDiscovery provides a comprehensive line of services for a wide range of proteins, including: • Custom protein array printing • Complete assay development and analysis • Protein profiling services • Technology transfer Each contract service project begins with the client specifying their proteins of interest. NanoInk’s dedicated Contract Research Organization then works in close consultation with the customer to design…
Assays for methylases, acetylases, phosphorylases and other modifying enzymes involved in histone and chromatin modulation are developed and optimized by RapidFire scientists for primary and secondary screens. Although histone modifying enzymes can be difficult to analyze by traditional methods, label-free RapidFire technology is well suited to this novel and emerging class of targets.
