Experience Better Productivity and Save Resources Too RapidFire data correlates identically with traditional LC-MS/MS methods Analyses are performed at a 10+ fold increase in cycle throughput, enabling us to provide 3 day turnaround RapidFire In Vitro ADME Analysis Services increase efficiencies while preserving your lab’s assay method integrity. We use the RapidFire 360 high-throughput TOF system to analyze CYP inhibition/ind…
Micro-ruled coverslip for cell culture with microscopic identification and measurement markers.
BlueScreen HC is based on the fast, accurate GreenScreen HC genotoxicity assay from Gentronix Ltd. BlueScreen HC uses the same human-derived, p53-competent TK6 cells to host a patented reporter system that exploits the proper regulation of the GADD45a gene. However, in place of GFP, BlueScreen HC utilizes a luciferase from the marine copepod Gaussia princeps to generate a luminescent output. The BlueScreen luminescent assa…
Predict pharmacokinetic properties from structure
High Content Analysis (HCA) is rapid, automated microscopy providing quantitative image acquisition and analysis. Using Millipore’s superior-quality reagents in ready-to-use kits and cell-based assays that incorporate the power of HCA, researchers around the world are able to learn more about relevant functional cell biology in many different systems, including assessment of DNA damage and apoptosis. Millipore’s HCA kits inclu…
BlueScreen HC uses a single cell strain, which permits 8 compounds to be tested across 8 dilutions (2-fold serial), together with untreated and positive controls, in one 96-well microplate. After arraying test compounds and dilutions, growing cells are added to each well. For studies without S9 metabolic activation data are collected after incubation (48h) using a multimode microplate reader. For studies incorporating S9 metab…
The cost of drug discovery continues to rise while the output of new NDAs continues to fall. Consequently it has never been more important to address attrition rates in drug discovery and development. Early indication of toxicity in a molecule or lead family means that discovery resources can be directed either at other chemical series if these are available or towards ‘breeding’ out undesirable properties. Gentronix and Apred…
FasL-Strep, a stable homotrimer, efficiently induces the CD95 pathway of apoptosis and is highly suited for evaluation of CD95 (Fas) receptor-ligand interaction. Human or murine FasL-Strep (CD95L-T4) is an engineered human or murine Fas (CD95) ligand. C-terminal fusion of the T4-FOLDON to the extracellular FasL (CD95L) receptor-binding domain (E142-L281) results in bioactive, conformationally stabilized, well defined trimers…
Frozen membranes from rat brain. (Cat#: A501)
Frozen membranes from rat brain. (Cat#: A502)
Frozen membranes from rat brain. (Cat#: A503)
Frozen membranes from rat brain. (Cat#: A504)
Frozen membranes from rat brain. (Cat#: A505)
