Drug discovery > Lead Discovery Products & Reviews

Not treated (or medium binding) polystyrene surface is hydrophobic in nature and binds biomolecules through passive interactions Is suitable primarily for the immobilization of large molecules, such as antibodies, that have large hydrophobic regions that can interact with the surface Untreated microplates have a binding capacity of approximately 100 to 200ng IgG/cm2 Without lids, lids supplied separately Total volume is…

Color-coded technical buffer solutions in plastic bottles Order No.      Type No.          pH value at 25 °C       Contents285139156   LC 4004 K     4.00                       250 ml in PE bottle285139189   LC 7004 K     7.00                       250 ml in PE bottle285139218   LC 1004 K     10.00                      250 ml in PE bottle Technical buffer solutions according to DIN 19 267 in canisters(preser ved with Thymol…

Flat bottoms with 360 µL total volume Recommended working volumes of 75 to 200 µL Treated for optimal cell attachment Nonreversible lids with condensation rings to reduce contamination Sterilized by gamma radiation and certified nonpyrogenic Individual alphanumeric codes for well identification Individually wrapped

Half Area 96 well UV microplate has a UV-transparent well bottom and is ideal for determining protein and/or nucleic acid concentrations Certified for low background and consistent performance at 260 and 280nm Certified DNase- and RNase-free UV-transparent bottom is molded directly to an acrylic base for greater strength and maximum leak resistance Half Area microplate has well volume of 205 µL; working volumes of 25 to…

Recommended working volume of up to 20 to 80 µL Conforms to standard microplate footprint and dimensions High binding surface binds medium (>10kD) and large biomolecules that possess ionic groups and/or hydrophobic regions Binding capacity is approximately 400 to 500ng IgG/cm2 Ideal for immunoassays

Feature uniform skirt heights for greater robotic gripping surface Solvent resistant polypropylene provides compatibility with many common organic solvents (e.g., DMSO, ethanol, methanol) Sterile and DNase- and RNase-free Total volume is 360 µL; recommended working well volume is 75 to 200 µL Without lids; lids, sealing mats and tapes supplied separately

High-quality microplates from Greiner Bio-One

The miVac DNA is an ideal small concentrator for the molecular biology laboratory. A centrifugal concentrator capable of removing water and organic solvents from a variety of sample formats including tubes, microplates and vials. Making it an ideal "work-horse" concentrator for the busy lab. The built-in special runs for working with water and water mixtures improve performance and optimise concentration time and make the m…

miVac is a range of centrifugal vacuum concentrators and freeze driers capable of removing water and organic solvents from a variety of sample formats including tubes, microplates, and vials. miVac concentrators come in 2 sizes, the smaller Duo and a larger Quattro. There is a choice of vacuum pump and rotor according to application and sample format.  To speed concentration built-in special runs for working with water and…

Unique frost free cold trap - the miVac SpeedTrap does not need  defrosting, all solvents (including water) collect as liquids and can be eaily emptied - collection jar is simply removed by quarter turn. The miVac SpeedTrap is compact, requiring little bench space and suitable for use with a wide range of solvents, from volatile organic solvents through to water and some of the higher boiling point solvents. The SpeedTrap i…

Double-beam, variable wavelength capability Programmable wavelengths: 190 - 900 nm East-to-use Control Pad Available Lamp startup/shutdown Pre-aligned lamps for easy changeover Remote autozero capability Optimized for use with ESA Coulometric electrochemical detection Low noise and low drift for increasing sensitivity and stability in analyses. The Model 526/528 detectors provide extremely low operating noise levels…

A low volume electrochemical cell optimized for the low flow rates of electrospray ionization mass spectrometry (ESI-MS). • Optimized for incorporation into low flow rate LC-MS applications • Provides high efficiency electrochemical conversion with minimal peak dispersion Proven Coulometric DesignThe Model 5030 Cell utilizes the proven porous graphite flow through design pioneered by ESA and is optimized for incorporation…

Not treated (or medium binding) polystyrene surface is hydrophobic in nature and binds biomolecules through passive interactions Is suitable primarily for the immobilization of large molecules, such as antibodies, that have large hydrophobic regions that can interact with the surface Binding capacity of approximately 250 ng of mouse IgG/cm2 EIA/RIA plates are tested on lot-to-lot basis and the certification results for ea…

Meet your lab's specific needs with outstanding flexibility and performance with the easy-to-use Thermo Scientific™ Multidrop™ Combi SMART + Reagent Dispenser, designed to support the varied requirements of pharmaceutical and biotechnology laboratories.

Three kits to cover a wide range of cAMP concentrations.After the introduction of IP-One, the first HTS immunoassay that can easily detect inositol(1)phosphate (IP1), a stable second messenger which tightly correlates with Gq-coupled receptor activity, the optimization of cAMP assays with the new HTRF® acceptor d2 offers a complete GPCR platform.The upgraded cAMP dynamic 2 and cAMP femto 2 assays, along with the new cAMP HiRa…

An easy way to assess tag accessibilityThe production of fusion proteins often raises the issues not only of their structural integrity after isolation, but also of the accessibility of the associated tag. In the case of GST or 6HIS tagged proteins, this verification can be achieved with HTRF® GST and 6HIS check kits. These two assays are competitive immunoassays in which the anti-GST or anti-6HIS Cryptate conjugates bind dire…

A rapid and sensitive homogeneous assay for cortisol assessmentThe HTRF® cortisol assay can be used for the quantification of cortisol in rodent serum, or directly on cells. This assay has also been validated for 11-beta HSD1 screening on whole cells or microsomes.The assay requires only 2 reagent additions, followed by an incubation period of 2 hours at room temperature. It has a detection limit of 70 pg/mL (e.g. 2 fmol/well…

A straightforward tool for biomolecular labeling with Europium cryptateThe Cryptate labeling kit includes all the necessary materials to allow rapid Cryptate labeling of various biomolecules and purification. The labeling reagent Eu3+-TBP-NHS Cryptate is suitable for labeling peptides, proteins, and oligonucleotides, as well as small molecules containing amino groups (N-terminus or lysine residues). The labeling procedure requ…

A range of HTRF® conjugates for assay developmentHTRF®  toolbox assembles a panel of detecting reagents such as Streptavidin-XLlent!, anti-tag antibodies like Eu-Cryptate anti-GST, 6HIS, DNP and anti species conjugated antibodies offering many possibilities for the study of molecular mechanisms. All reagents are available as Cryptate-Europium or XL665 (the two HTRF tracers) conjugates, to allow easy assay development. These re…

The assay involves two monoclonal antibodies, one labeled with Cryptate and the other with XL665, that recognize distinct determinants. The assay is performed in a single step and requires only a short incubation period. Detection limit of the assay is 0.20 ng/mL and the linear range covers 0.3 to 10 ng/mL. The assay has been validated on various biological material including isolated perfused pancreas, plasma, and pancreatic…

Streamlined single plate protocols including all stimulation and cytokine quantification.The HTRFâ cytokine kit line includes TNFa, IFNg, IL1b, IL6 and IL8 assays. These assays feature no separation steps, a high sensitivity and dynamics, and no use of isotopes. Procedures are performed on a single plate with simultaneous cell stimulation and cytokine detection. They can all be run under a similar experimental procedure stream…

A new secondary messenger for Gq coupled receptor investigation.Cisbio’s IP-One assay, based on its proprietary HTRF® technology, is the first HTS immunoassay that can easily detect inositol(1)phosphate (IP1), a stable second messenger which tightly correlates with Gq-coupled receptor activity. This assay displays all the characteristic advantages of an HTRF® system: totally homogeneous, detection via fluorescence, signal stab…

A fast and reliable process for biomolecule labelingIn many circumstances, assay development and HTS involve specific labeling of the various assay components. Cisbio international’s labeling service is an excellent alternative for the labeling of proteins, peptides, oligonucleotides, or other biomolecules either with Cryptate, XL665, biotin or DNP when you do not have the time or the facilities to label them yourself.Two type…

Rapid Analysis of Multiple 2D Gel Sets DYMENSION 2 has all the features of DYMENSION 1 but has the added ability to detect and compare protein spot maps in multiple gel sets. The software offers many background correction and noise filtering features including a SYPRO® Ruby filter, which can detect and automatically remove spots caused by SYPRO® Ruby crystals adhering to the gel, thus saving users valuable time editing the…

Quick and Easy Analysis of all 2D Gel Applications The exciting DYMENSION 3 software has all the functionality of DYMENSION 2, so can be used to analyse multiple gel sets. In addition, DYMENSION 3 is capable of analysing multi-stained fluorescent gel images stained with up to three contrasting fluorescent labels, for example, Cy™2, Cy™3 and Cy™5. This feature allows users to analyse multiple sets of any type of 2D protein…