Drug discovery > Lead Discovery Products & Reviews

Chemicon's cloned human CGRP1-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant CGRP1 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between CGRP1 and its ligands.

Chemicon's cloned human S1P1-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant S1P1 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between S1P1 and its ligands.

EMD Millipore's S1P1 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of S1P1 interaction with its ligands. The cell line exhibits a calcium response with EC50s of 141 μM for Sphingosine 1-phosphate. The membrane preparations exhibit EC50s of 9.5 μM for Sphingosine 1-phospha…

Chemicon's cloned human PK2-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant PK2 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between PK2 and its ligands.

Chemicon's cloned human EP2-expressing cell line is made in the Chem-9 host, which supports high levels of recombinant EP2 expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between EP2 and its ligands.

EMD Millipore's EP2 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of agonists and antagonists of EP2. The membrane preparations exhibit a Kd of 14.52 nM for [3H]-PGE2. With 7.5 nM [3H]-PGE2, 10µg/well EP2 Membrane Prep typically yields greater than 3-fold signal-to-backgr…

EMD Millipore’s cloned human Ghrelin Receptor-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant Ghrelin Receptor expression on the cell surface and contains high levels of the promiscuous G protein to enhance coupling of the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists and antagonists at Ghrelin Receptor.

EMD Millipore's Ghrelin Receptor membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of ghrelin interactions and its ligands. The membrane preparations exhibit a Kd of 0.32 nM for [125I]-ghrelin. With 0.1 nM [125I]-ghrelin, 5 μg/well Ghrelin Receptor Membrane Pre…

Chemicon's cloned human S1P4-expressing cell line is made in the Chem-5 host, which supports high levels of recombinant S1P4 expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between S1P4 and its ligands.

EMD Millipore's cloned human S1P5-expressing cell line is made in the Chem-5 host, which supports high levels of recombinant S1P5 expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between S1P5 and its ligands.

EMD Millipore's S1P5 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of S1P5 interactions with its ligands. The membrane preparations exhibit EC50s of 2.4 nM for S1P in a GTPγS binding assay.

EMD Millipore’s cloned human GPR92 -expressing cell line is made in the Chem-1 host, which supports high levels of recombinant GPR92 expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists and antagonists at GPR92.

EMD Millipore’s cloned human GPR91 -expressing cell line is made in the Chem-1 host, which supports high levels of recombinant GPR91 expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists and antagonists at GPR91.

Chemicon's Wild-Type Chem-1 cell line is a control for Chemicon's GPCR-expressing Chem-1 calcium-optimized cell lines. The Chem-1 cell line is adherent to tissue culture-treated surfaces and contains high levels of the promiscuous G protein Galpha15 to couple many classes of GPCRs to the calcium signaling pathway.

Residual Gas Analyzer - RGA100, RGA200 and RGA300 100, 200 and 300 amu systems Better than 1 amu resolution 6 orders of magnitude dynamic range in a single scan 5 x 10-14 Torr detection limit RGA Windows and LabVIEW software Field-replaceable electron multiplier and filament RS-232 (std.) and Ethernet (opt.) interfaces Features and benefits The 100, 200 and 300 amu residual gas analyzers from SRS offer excepti…

The solid phase extraction (SPE) workstation can be used on Xiril pipetting workstations for automated nucleic acid purification based on vacuum technology. All pipetting steps of several different nucleic acid purification kits can be automated on a Xiril liquid handling workstation. Xiril’s very space saving SPE vacuum station comprises two positions, one in the front for washing steps and another in the back for the elution…

The magnetic bead separation device Magnetic PlateX can be used with a Xiril pipetting workstation for automated nucleic acid purification based on the magnetic beads technology. Speed up the process of nucleic acid purification with a magnetic beads kit using the Magnetic PlateX on a Xiril robotic workstation. All pipetting steps are taken over by the robot and the plate gripper “Plate GripX” automatically carries out the tra…

The Plate-ScanX enables microplate identification for data tracking in an automated liquid handling process on a Xiril robotic workstation. Xiril’s plate scanner device allows reading of 1D and 2D barcodes on the side of microplates. The plate gripper of the Xiril liquid handling workstation picks up the plate and presents it in front of the barcode scanner camera.

The Plate-TempX low profile heating & cooling device to temper microtiter plates during an automated liquid handling process can be mounted on a Xiril pipetting workstation. The Plate-TempX station – based on Peltier technology – allows incubation of a microplate in a temperature range of +4 to +70°C. Specific adapters for flat-bottom, round-bottom and PCR plates ensure efficient temperature transfer throughout the incubation…

Speed up your automated procedures and increase the throughput of your pipetting processes with 96 channels working in parallel! Xiril’s liquid handling workstations Neon100 and Neon150 can be equipped with a 96 channel pipetting head, using air displacement technology. The pipetting range from 3-200µl allows liquid transfers into 96- and 384well micro- and deep well plates in both single- and multi-pipetting modes. The 96 cha…

With innovative 45/0 design HunterLab’s next generation Color Flex EZ spectrophotometer takes color quality control to its highest level with 45/0 design for the ultimate in color measurement preciseness. Combining versatility, simplicity and performance, the ColorFlex EZ reflects almost 60 years of color measurement innovation in one easy-to-use, compact instrument from the world’s most trusted leader in color quality. The Co…

Thermo Scientific Nunclon Vita is a unique energy-treated polystyrene surface that enables growth of most cell lines directly on the surface without using matrix coatings or feeder cells. Thermo Scientific Nunclon Vita is the latest addition to an exceptional portfolio of cell culture surface products, including the Thermo Scientific Nunclon Delta surface, and joins an extensive range of technologies and products for all basic…

The compact, lower capacity FC 203B Fraction Collector collects samples based on time, drop, or peak, making it a choice for a range of LC applications. The collector accommodates a wide variety of collection vessels, including microplates, vials, and tubes and can be used with any HPLC system.

The FC 204 Fraction Collector is a compact, large-bed fraction collector with a large capacity capable of handling test tubes, vials, and up to eight shallow or deep well microplates. Fractions can be collected by drop, peak, or time, and the collector can be used with any HPLC system.

CHIRAL TECHNOLOGIES offers an expanded line of immobilized polysaccharide chiral stationary phases (CSPs), CHIRALPAK IA™, IB™, and IC™. These immobilized CSPs allow the use of a highly extended range of solvents and offer new separation selectivities relative to conventionally coated CSPs. All three are based on high-efficiency 5-µm diameter spherical silica (or 20-µm for scale-up to semi-preparative and preparative applicatio…