Drug discovery > Lead Discovery Products & Reviews

Agilent Mass Profiler Professional (MPP) software is a powerful chemometrics platform designed to exploit the high information content of MS data and can be used in any MS-based differential analysis to determine relationships among two or more sample groups and variables. 

The Agilent MassHunter METLIN Metabolomics Database and Library enable streamlined metabolite identification to facilitate understanding of global metabolic changes that can occur in a biological system. Available as a comprehensive database of metabolites (PCD) that optionally includes MS/MS spectra (PCDL).

The 1260 Infinity II Bio-Inert Pump is a quaternary UHPLC pump that is made of bio-inert material for use in biological and extreme pH applications. This pump enables gradient formation and solvent blending from up to four solvents and operates at pressures up to 600 bar and flow rates up to 10 mL/min.

The 1260 Infinity II Preparative Fraction Collector is optimized for laboratories performing semipreparative-scale purification of milligram to low gram quantities with typical flow rates between 4 and 100 mL/min. The module features the full set of collection modes and is compatible with a wide variety of trigger sources. SBS plates and four different tube sizes with various lengths are supported.

The 1260 Infinity II Preparative Autosampler is designed for automated sample handling in routine purification applications. This flow-through vialsampler supports preparative flow rates of 200 mL/min and 600 bar pressure. Increase your daily throughput of purified sample by injecting up to 132 preparative samples with a maximum of 3.6 mL volume.

The 1260 Infinity II Preparative Binary Pump is an affordable high-pressure gradient pump for LC purification. The pump offers a dynamic flow rate range from 1 to 50 mL/min at up to 420 bar, allowing workflows on columns from 9.4 to 30 mm inner diameter.

The 1290 Infinity II Refractive Index Detector (RID) is a UHPLC RID detector that provides excellent sensitivity, resolution, and sample throughput for UHPLC DRI experiments. The 1290 Infinity II RID is a equipped with an ultralow dispersion microflow cell and a data rate of 148 Hz, which significantly reduces run times for higher sample throughput and improved resolution and sensitivity.

The 1260 Infinity II Degasser is suitable for analytical applications with flow rates up to 10 mL/min and up to four solvents. It is highly recommended for GPC/SEC applications using refractive index detection. It reduces baseline noise and quenching effects due to high degassing capacity.

The Agilent DNA Fish ID solution uses advanced software to achieve more accurate results – quickly and easily. Key to the process is the Agilent 2100 Bioanalyzer and RFLP Decoder Software performs RFLP pattern matching, which eliminates the need for manual calling

The Mx3005P system is among the most reliable and trusted QPCR instruments available, with a long record of citation in peer-review journals. The Agilent Mx3005P and Mx3000P QPCR Systems are the most flexible—and reliable—instruments available for gene expression analysis, microarray data validation, SNP genotyping, pathogen detection, DNA methylation analysis, and chromatin immuno-precipitation studies.Highly reproducible re…

These Gilson engineered caps produce a positive pressure seal with the needle in the Gilson ASPEC, ASPEC XL and ASPEC XL4 solid phase extraction systems.

Bond Elut 96 Square-well Plates are specially designed to offer superior cleanliness, flow reproducibility, and reliability, ensuring trouble-free, high throughput operation. Conversion of cartridge-based methods to an automation-friendly 96-well plate format has never been easier or faster.

Bond Elut AccuCAT cartridges are mixed bed SPE cartridges consisting of a strong cation exchange (SCX) and a strong anion exchange (SAX) sorbent packed into one bed. AccuCAT is effective for the extraction of acidic, basic, and neutral analytes from urine and other biological samples. AccuCAT is particularly effective for catecholamine extraction from biofluids.

Bond Elut adapters fit on top of any Bond Elut cartridge and contain a female Luer fitting that accommodates the tip of another cartridge.

Alumina, like silica, is an extremely polar sorbent. The alumina surface tends to be slightly more stable under high pH conditions than unfunctionalized silica. The small particle size of the Bond Elut Alumina range ensures high extraction efficiency even when small bed masses are used.

Due to the methyl group and subsequent low carbon load, Bond Elut C1 is the least retentive of all alkyl group bonded phases for nonpolar compounds. However, due to the extensive endcapping of this sorbent to mask polar silanol activity, retention, and elution of polar and multifunctional analytes can still be achieved.

Bond Elut C18 is the most hydrophobic, bonded silica sorbent available in the Bond Elut range. It is the most popular SPE sorbent because of its extreme retentive nature for nonpolar compounds. C18 is generally regarded as having the broadest spectrum of retention among bonded silica sorbents, since it retains most organic analytes from aqueous matrices. 

Bond Elut EWP is based upon standard particles size silica but with 500 pores to allow more efficient extraction of large molecules (>15,000 MW), which are typically excluded from standard porosity silica phases.

Bond Elut C18 OH is a nonendcapped version of the octadecyl bonded phases that enables the silanols on the silica surface to be more active. This low-load C18 has well-controlled silanol activity that permits the fractionation of metabolites and enhances retention of basic compounds compared to an endcapped C18. The pore size makes it a good choice for peptide extraction.

Bond Elut C2 is a fairly nonpolar sorbent because of the short chain length of the functional group. C2 is often used during the process of method development if analytes are retained too strongly on a C8 or C18 phase. The polarity of C2 is slightly lower than a cyano phase for polar interactions.

Bond Elut C8 is very similar in property to C18, but is not as retentive for nonpolar compounds due to its shorter hydrocarbon chain and therefore reduced carbon loading. C8 is an excellent replacement for C18 when analytes are too strongly retained for effective elution. 

Bond Elut Carbon cartridges are packed with ultrapure graphitized carbon particles that have been optimized for the absorption of pigments in food, fruits and vegetables, and small organic residues in wastewater. The powerful retention mechanisms of these products are appropriate for a broad range of analytes. In addition, careful manufacturing techniques result in lower carbon fines on the wall of the device.

CBA is a midpolarity sorbent and weak cation exchanger (pKa 4.8). It can be used with a wider range of counterions than lower pKa sorbents like SCX, and will demonstrate easier elution of quaternary amine functionalized analytes.

Bond Elut Cellulose columns utilize a pure microgranular cellulose powder that is packed between two, 20 µm polyethylene frits. The cellulose phase is very stable over a wide pH range and contains an extremely low metal content (Fe and CU content less than 5 ppm). 

The Bond Elut Certify extraction cartridge utilizes a packed bed consisting of a special, nonpolar C8 sorbent and a strong cation exchanger (SCX). Certify is most commonly used to extract basic (cationic) drugs from urine and blood, but it is also very effective for extracting a wide range of compounds from a diverse number of aqueous matrices.