Drug discovery > Lead Discovery Products & Reviews

Achieve faster run times and improved sensitivity with a smaller particle size

SunFire™ columns feature excellent low pH stability and improved column lifetime compared to many silica-based HPLC column brands. SunFire columns are packed with state-of-the-art silica and new proprietary C18 and C8 bonding and endcapping for high efficiency, resulting in greater sensitivity.  SunFire columns are manufactured to achieve the highest level of chromatographic consistency column-to-column and batch-to-batch. MS-…

Excellent low pH stability and high mass loading capability

ACQUITY UPLC® BEH C18 and C8 columns were designed to be the universal columns of choice for most UPLC® separations by providing the widest pH range.They incorporate trifunctional ligand bonding chemistries which produce superior low pH stability and ultra-low column bleed. This low pH stability is combined with the high pH stability of the 1.7 µm BEH particle to deliver the widest usable pH operating range. In addition, these…

ACQUITY UPLC® BEH Shield RP18 columns combine Waters patented Shield Technology* with BEH Technology™ by incorporating an embedded carbamate group into the bonded phase ligand.Waters shield ligands consistently demonstrate increased retention of phenolic compounds versus straight chain alkyl columns. The alternate selectivity and excellent peak shape from the embedded polar group ligand, when combined with the wide pH range an…

ACQUITY UPLC® BEH Phenyl columns utilize a trifunctional C6 alkyl tether between the phenyl ring and the silyl functionality. This ligand, combined with the same proprietary endcapping processes as the ACQUITY UPLC™ BEH C18 and C8 columns, provides ultra-low column bleed, long column lifetimes and excellent peak shape. This unique combination of ligand and endcap on the 1.7 μm BEH particle creates a new dimension in selectivi…

ACQUITY UPLC® BEH HILIC columns contain the rugged 1.7 μm unbonded BEH particles and are designed to retain and separate very polar basic compounds.These unique columns are optimized and tested to produce efficient and reproducible separations under UPLC® HILIC conditions. ACQUITY UPLC BEH HILIC columns overcome a major weakness of HILIC stationary phases: chemical stability. The unbonded silica stationary phases often used in…

Waters offers a broad range of vials, each one is held to tight dimensional tolerances and the certified products have cleanliness measured by LC and MS.LC/GC Certified vials are tested by LC/UV for residues of chemicals used in processing and packaging vials. The septa are tested by headspace GC to ensure low levels of low molecular weight polymer. These vials are suited for analyte concentration in the µg/mL concentration; t…

The Waters IdentityE High Definition Proteomics system defines the new standard for rigorous protein identification. The IdentityE High Definition Proteomics System is an UltraPerformance LC® (UPLC)/High-Bandwidth Mass Spectrometry (MS E) system solution suitable for confident protein identification designed to meet stringent requirements as outlined by leading scientific journals.The new Waters IdentityE High Definition Pro…

Run assays up to 5 times faster than a conventional HPLC. Increase mass spec sample throughput by a factor of 5. Eliminate dead time in your analysis and cut solvent usage by 99 percent. Achieve all this and more with the ExpressLC-100 system. TheExpressLC-100 system is a single-channel HPLC with binary solvent delivery, high pressure gradient mixing, variable volume injection, UV absorbance detection, and PC-based instrument…

The new Guava Nexin® reagent monitors induction of apoptosis quickly and easily, with minimal chance for contamination. Annexin V is a calcium-dependent phospholipid binding protein with high affinity for phosphatidylserine (PS), a membrane component normally localized to the internal face of the cell membrane. Early in the apoptotic pathway, molecules of PS are translocated to the outer surface of the cell membrane where Ann…

A novel thermoreversible gel mountant for temporary immobilization and imaging.

Millipore's full-length mTOR kinase is now available as part of the KinaseProfiler™ Service. This kinase is the first biologically relevant mTOR to be commercially available. The KinaseProfiler Service offers 264 kinases for selectivity profiling, using a catalytic radiometric assay format. The addition of the full-length mTOR to the KinaseProfiler panel provides high-quality, confidential screening of compounds against this c…

High Throughput SonicationFeatures: Stand-alone instrument 96, 384, and 1536 interchangeable disposable pinned lid technology Plate shuttle allows for direct integration with pick & place robotics. Variable power settings between 1 and 1150 watts. Variable sonication time intervals from 0.1 to 20 seconds.

The Picovitro plates are optimal diagnostic tools for studying thousands of individual living cells in real time, applicable on both adherent and non-adherent cells for short-term (72 hours) or long-term (10-14 days) analysis. This MicroTiter plate format is available with 3243 wells. It is compatible with standard instruments, e.g., flow cytometer with sorting capabilities.

The Picovitro plates are optimal diagnostic tools for studying thousands of individual living cells in real time, applicable on both adherent and non-adherent cells for short-term (72 hours) or long-term (10-14 days) analysis. This MicroArray format is available with 672 wells. It is compatible with standard instruments, e.g., flow cytometer with sorting capabilities.

An orange probe staining both nucleus and cytoplasm.

Aitken Scientific have created a software product called A-S Login (fully validated to GAMP standards) which will enable the pharmaceutical industry and its suppliers to minimise cost and time when implementing the requirements of 21 CFR Part 11.     • Maintains permitted applications, allowing versions and access rights to be controlled.     • Maintains the list of authorised users             o Password administration…

Aitken Scientific provide a service of software and hardware integration to a broad range of clients. These clients are mainly based in pharmaceuticals, engineering, scientific research, instrumentation and manufacturing. We work with small start-ups to major international companies delivering solutions across the world. We have worked with one major pharmaceutical company for many years on over 40 projects and had very positi…

ACTOR™ (Automated crystal transport orientation and retrieval robot) is a proven commercial solution for automating routine crystal screening and data collection at both synchrotron beam lines and home laboratories. Compatible with almost any goniometer and detector combination, the ACTOR eliminates much of the physical handling of samples required during crystal screening and data collection. ACTOR allows you to screen up to…

Application The Cytotoxicity Detection KitPLUS (LDH) is a fast, sensitive, and simple method to quantitate cytotoxicity/cytolysis based on the measurement of LDH activity released from damaged cells using the 96-well or 384-well plate format. The kit can be used in many different in vitro cell systems when damage to the plasma membrane occurs. For example: Detection and quantification of cell-mediated cytotoxicity. Deter…

Application The Cell Proliferation Reagent WST-1 is designed to be used for the nonradioactive, spectrophotometric quantification of cell proliferation and viability in cell populations using the 96-well-plate format. It can be used for: Measurement of cell proliferation in response to growth factors, cytokines, mitogens, and nutrients Analysis of cytotoxic and cytostatic compounds, such as anti-cancer drugs and other ph…

ApplicationSamples suitable for the Caspase 3 Activity Assay are: Lysates of apoptosis-induced cells Recombinant caspase 3 (CPP32) The Caspase 3 Activity Assay can be used to: Detect and quantify in vitro caspase 3 activity in cell lysates Analyze caspase 1, 2, 3, or 7 activity by simply omitting the capture-antibody step Perform inhibitor studies for Caspase 3 This kit is intended as a tool for life science…

THE MOBILE SOLUTION

The basic system is a counter with sample trays holding either 40 (5x8) 20 ml vials or 96 (8x12) 7ml vials. The counter has a pneumatic arm which is loading the samples to the detector chamber. The counter has a unique three PMT detector which enables Triple to Double Coinciencidence Ratio counting. This enables easy determination of sample counting effiency without any external or internal standard. The counter will have an o…