Drug discovery > Basic Research Products & Reviews

Column-based method for rapid concentration and cleanup of RNA.

Isolate High-Molecular-Weight DNA for Long-Read-Sequencing applications.

LDH-Glo™ Cytotoxicity Assay detects cell death from a small number of cells, including 3D cell cultures, based on the release of lactate dehydrogenase.

The RealTime-Glo™ Annexin V Apoptosis and Necrosis Assay provides a no-wash, one-step Annexin V assay that allows continual monitoring of cell state to determine apoptotic onset using a plate-reading luminometer.

The GSH/GSSG-Glo™ Assay is a bioluminescent assay to detect and quantitate total glutathione ratios.

The Caspase-Glo ® 1 Inflammasome Assay  directly measures inflammasome activation with a simple add-mix-measure protocol.

Antibody-dependent cell-mediated cytotoxicity (ADCC) is a mechanism of action of antibodies through which virus-infected or other diseased cells are targeted for destruntion by components of the cell-mediated.

The TNT® Coupled Reticulocyte Lysate Systems offer researchers an alternative for eukaryotic cell-free protein expression: a single-tube, coupled transcription/translation system. The TNT® Lysate Systems greatly simplify the process and reduce the time required to obtain in vitro translation results.

Wizard® Plus Megapreps DNA Purification System provides a simple and rapid method for large-scale purifications of plasmid DNA that eliminates the need for cesium chloride:ethidium bromide gradient centrifugation. Use of this system requires only a centrifuge, a vacuum source and a vacuum manifold. The system yields greater than one milligram of high-copy-number plasmid DNA (200–20,000bp) from a 1,000ml culture in less than th…

ProteaseMax™ Surfactant is a high-quality reagent for use in protein and peptide sample preparation.   ProteaseMax™ Surfactant solubilizes proteins and ensures fast and improved protein digestion with trypsin or chymotrypsin. It is designed to degrade over the course of a digestion reaction, yielding products that are compatible with downstream methods such as mass spectrometry (MS) and liquid chromatography (LC). For…

Cleaning various items used in ultra-trace analysis work is a critically important laboratory routine. traceCLEAN assures best cleaning quality of your TFM, glass and quartz parts for ICP/ICP-MS accessories. Any trace metal contaminants stay within the reservoir and do not come in contact with the cleaned trace accessories. The cleaning process with the traceCLEAN takes about an hour, enhancing the overall lab workflow. 

Predesigned probe assays for gene expression analysis

Custom adapters for multiplex next-generation sequencing

Predesigned primers for gene expression analysis

Specialized purification to ensure high performance

Larger quantities for in vivo, high throughput and commercial projects  

If you commercialize Molecular Diagnostics (MDx), create Laboratory Developed Tests (LDTs), or conduct preclinical research, then your final kit, assay, or modality must have an extraordinary level of quality to comply with strict regulatory or study standards. In the case of oligonucleotide raw materials available with custom specifications, the only option you should consider is Custom cGMP Oligos.

Modulation of gene expression with modified oligos

Proteinase K from Tritirachium album ELEVATE  

Proteinase K from Tritirachium album ELEVATE

The Universal Vacuum Manifold system accommodates 24, 48 and 96 well plate configurations. This system includes a collection plate, extraction plate, manifold and vacuum gauge waste base for all wellplates.

Complete Vacuum Manifold System includes a glass block, Corian® manifold lid, a cover gasket, a vacuum gauge and valve assembly, teflon tips (16 or 24), an adjustable collection rack, bulkhead luer fittings, plugs (16 or 24), and manifold safety tray.

Stainless Steel Manifold -available in single, 3 and 6 station designs. The 3 and 6 multi-station manifolds allow the simultaneous processing of multiple samples.

As therapeutic molecules become more complex, developing cell lines that make high yield, high-quality product has become more challenging. Opto Assure makes earlier assessment of product quality possible, so you get the best cells and a faster, lower-risk path to volume production – even for complex molecules like bispecifics.

With the Beacon system’s light-speed workflows, you’ll gain insights, iterate and innovate. Replace a roomful of equipment with the Beacon system Work fast with individual cells  Perform assays at any time, as often as you need Track phenotype and genotype of single cells or clones Automate and scale workflows beyond manual, time-intensive analysis Generate great insights through deep profiling of each cell or clone