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CRISPRi Libraries, Pools, and gRNAs

Merck

Nuclease-independent applications of CRISPR provide equal targeting specificity but instead of cutting, CRISPRi allows for targeted interference of gene function by delivering transcriptional repressor domains to a specific target sequence using modified dCas9 + gRNA complexes. Gene knockdown is complementary to CRISPR-KO and CRISPRa (activation) and has distinct advantages over existing loss-of-function strategies like RNAi.…

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Steritest™ Sterility Media

Merck

Sterility testing culture media and rinsing fluids are critical components of your Steritest™ solution. They provide the highest level of quality and testing confidence, they have been formulated and tested to meet the requirements of the USP <71>, EU Pharmacopoeia < 2.6.1> and JP Pharmacopoeia <4.06>. Steritest™ sterility culture media and rinsing solutions are manufactured in an ISO 9001, environmentally controlled productio…

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ProductsGeneral Lab

Curcumin

Merck

Curcumin is a yellow-colored polyphenol obtained from the rhizome of Curcuma longa L. It constitutes an important part of various diets and herbal medicines, especially in the Asian continent for its various salubrious effects on human health. Application Curcumin has been used: to study its effect on the consequences and mechanism involved in the suppression of human homeobox gene NKX3.1 in the prostate cancer cell…

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Products

Nafion™

Merck

Nafion ™  is a perfluorosulfonic acid nafion resin that is majorly used as a strong solid acid (H 0  -12) with high thermal stability and chemical resistance.

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ProductsSeparations

5α-Dihydrotestosterone (DHT) solution

Merck

Also known as androstanolone or DHT, 5α-Dihydrotestosterone is an androgen or male sex hormone that has been implicated in a broad range of disease from male pattern baldness to benign prostatic hyperplasia and prostate cancer. As an anabolic steroid, DHT has also been used as a performance-enhancing drug to promote muscle growth. This Certified Spiking Solution® is suitable for GC/MS and LC/MS applications from clinical and d…

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ProductsGeneral Lab

Certipur® pH Reference Buffer Solutions in Practical Sachets

Merck

If you want precision and reliable measurements combined with ease of use, Merck offers you a range of certified, ready-to-use Certipur® buffer solutions with exact reference pH values safely packed in sealed sachets. Preparation effort is thus reduced to a minimum: Just open the sachet and start calibrating. The buffer solutions come in small and handy single-use quantities (30 ml) and are always fresh, without residues and…

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ProductsSeparations

Chromolith® HPLC Columns

Merck

Monolithic silica-based Chromolith® HPLC columns allow rapid separations at very low column backpressure with high matrix tolerance and extended column lifetime, thus making them ideal products for high throughput and cost-efficient analyses of matrix-rich samples. 

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ProductsSeparations

SeQuant® HILIC

Merck

SeQuant ® HILIC (hydrophilic interaction liquid chromatography) HPLC columns carry densely bonded, zwitterionic functional groups. These columns are available in a variety of lengths, particle sizes, and pore dimensions while showing an exceptional reproducibility and robustness.

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ProductsSeparations

Chromolith® WP 300 HPLC Columns

Merck

Chromolith ®  columns have shown great potential and superiority in comparison to standard silica. In contrast to conventional, packed-particle columns, wide pore (300 Å) monolithic silica columns are made of a single continuous-bed rod of high purity porous silica that is then bonded with C18, C8, C4, Epoxy, and Protein A depending on the use of the column.

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Bacterial Gene Editing with CRISPR

Merck

CRISPR/Cas9-mediated recombineering is the most powerful bacterial genome engineering method to date. In addition, Cas9-mediated recombineering overcomes the dependence on a second recombination step, avoids the creation of destabilizing scar sites, can be used in multiplexing, and is less time-consuming than previous protocols.

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