Merck Drug discovery > Lead Discovery Products & Reviews

Samplicity G2 Starter Bundle (Glossy Green) with 0.45 µm Millex-GP Filters

Solution Stable Enzyme for Mass Spectrometry

Supel ™  Genie Online SPE cartridges are a sample preparation solution that offer a seamless workflow from start to finish performed entirely  'online' the LC instrument. Typically, an autosampler would take the samples from a collection plate or tubes, and inject them directly onto the SPE cartridge located on the analytical instrument (LC instrument). This enables an entirely hands free workflow which eliminates the risk o…

Supel™ Genie HybridSPE® online cartridges have been developed as an alternative to traditional 96-well plate and individual cartridge formats for phospholipid removal and sample preparation. The HybridSPE online cartridges have been designed for online phospholipid removal allowing direct injection of protein precipitated samples for LC/MS analysis. When the samples flow through the HybridSPE online traps, the phospholipids ar…

Lyophilized powder, ≥96% (agarose gel electrophoresis)

BIOshell™ HPLC and UHPLC columns deliver maximum speed and efficiency for the separation of biomolecules on both HPLC and UHPLC systems. The novel, superficially porous silica particles (SPP), with pore sizes from 90 Å up to 1000 Å, allow the separation of glycans as well as of very large proteins.

The Fused-Core ® particle technology behind Ascentis ® Express columns delivers maximum speed and efficiency on both HPLC and UHPLC systems. The novel superficially porous silica particles (SPP) are available in three different particle sizes and two different pore sizes for optimal suitability from micro over UHPLC and HPLC to semi-preparative use.

For perfect high-performance liquid chromatography (HPLC) results, high-performance solvents are a must. LiChrosolv ® solvents are designed to optimally support analytical HPLC, fast chromatography, and LC-MS applications. They feature high degrees of UV transmittance, low particle counts, low acidity and alkalinity, and low evaporation residue levels making them ideal for reproducible separations.

Our HybridSPE ® -PLus plates effectively remove phospholipids and proteins from biological matrices in a simple pass-through method for accurate and reproducible LC-MS analysis. Unlike other phospholipid removal SPE products on the market, the unique retention mechanism of HybridSPE ® allows for separation of even very hydrophobic analytes from phospholipid contaminants.     

Supel™ Swift HLB is a polymeric stationary phase for solid phase extraction (SPE) prior to instrumental analysis. It has both hydrophilic and lipophilic functional groups for the extraction of a broad range of compounds from aqueous samples. It retains analytes having diff erent polarities and Log P values due to its hydrophilic and lipophilic balance (HLB) property.

Graphitized Non-Porous Carbon  

Supel™ BioSPME 96-Pin Devices were developed to greatly improve upon the speed and simplicity plasma protein binding studies and other free analyte analyses.  Our technology offers a 3x faster workflow compared to rapid equilibrium dialysis based methods, is amenable to both automation and manual operation, and is a convenient universal 96-pin format compatible with standard 96-well consumables.  

MS β-glucuronidase is a prebuffered, bench-stable, and automation-ready hydrolysis mix for urine drug testing workflows. Discover how to leverage its reduced hands-on time and improved stability. 

Silver nitrate powder, extra pure

Also known as androstanolone or DHT, 5α-Dihydrotestosterone is an androgen or male sex hormone that has been implicated in a broad range of disease from male pattern baldness to benign prostatic hyperplasia and prostate cancer. As an anabolic steroid, DHT has also been used as a performance-enhancing drug to promote muscle growth. This Certified Spiking Solution® is suitable for GC/MS and LC/MS applications from clinical and d…

Monolithic silica-based Chromolith® HPLC columns allow rapid separations at very low column backpressure with high matrix tolerance and extended column lifetime, thus making them ideal products for high throughput and cost-efficient analyses of matrix-rich samples. 

SeQuant ® HILIC (hydrophilic interaction liquid chromatography) HPLC columns carry densely bonded, zwitterionic functional groups. These columns are available in a variety of lengths, particle sizes, and pore dimensions while showing an exceptional reproducibility and robustness.

Chromolith ®  columns have shown great potential and superiority in comparison to standard silica. In contrast to conventional, packed-particle columns, wide pore (300 Å) monolithic silica columns are made of a single continuous-bed rod of high purity porous silica that is then bonded with C18, C8, C4, Epoxy, and Protein A depending on the use of the column.

Accurate Photometric analysis for Water, Environmental, Food and Beverage Testing

Spectroquant ® tests and kits for accurate, precise and consistent results

Accurate colorimetric analysis for Water, Environmental, Food, and Beverage Testing on the go and anywhere!

Supel™ Swift HLB is a polymeric stationary phase for solid phase extraction (SPE) prior to instrumental analysis. It has both hydrophilic and lipophilic functional groups for the extraction of a broad range of compounds from aqueous samples. It retains analytes having diff erent polarities and Log P values due to its hydrophilic and lipophilic balance (HLB) property.

Our Smart SPME fibers are equipped with a unique Smart chip that offers traceability, ease-of-use, and increased productivity. The smart SPME fibers are an extension of our expertise and innovation from traditional SPME coatings to smart SPME format for accurate, reliable, and consistent results.

The over coating of fibers is a new technology in fiber coating to protect the SPME fiber from matrix components. This allows for immersion of the fiber directly into complex samples ensuring a more efficient extraction (e.g. of semivolatile compounds). Polydimethylsiloxane (PDMS) is used to overcoat a PDMS/divinylbenzene (DVB) fiber. The resulting fiber is more physically robust and resistant to chemical fouling and allows f…

The nitinol-core of SPME fibers enhances the fiber performance and the precision of chromatographic results to enhance lot-to-lot and fiber-to-fiber reproducibility, increase fiber durability, and maintain selectivity and inertness compared to fused silica core fibers.