Agilent Technologies Drug discovery > Basic Research Products & Reviews

The GeneMorph II Random Mutagenesis Kits have been formulated to produce a more uniform mutational spectrum when performing error prone PCR to achieve random mutagenesis. Other methods or commercially available kits that rely on Taq DNA polymerase for random mutagenesis have shown biases towards mutating A’s and T’s more frequently than G’s and C’s, which undoubtedly skews representation of random mutant libraries.

Agilent’s Absolutely RNA Product portfolio makes RNA purification from tissue and cell samples easy and fast. Absolutely RNA kits include all the reagents you need for DNA-free total RNA, and miRNA isolation with no additional purchase of DNase required. No heating, no long centrifugation, and no repurification is required. Each absolutely RNA purification kit has been optimized for a specific range of sample sizes and elutio…

Determine if a gene product or compound activates pathways leading to specific enhancers with our PathDetect Cis-Reporting Systems.  When PathDetect cis-reporting and expression plasmids encoding your gene of interest are co-transfected into mammalian cells, increased reporter activity indicates transcription activation and involvement of your gene product in the pathway leading to the enhancer element  

Determine the direct or indirect involvement of new gene products, growth factors, and drug candidates in specific pathways with our PathDetect Trans-Reporting Systems.  Easily investigate whether your protein or compound influences the activation of any of the six transcription factors offered.  These systems are available as plasmid vectors with a luciferase reporter for co-transfection with your gene of interest into the c…

Agilent’s market leading SureSelect platform provides a complete portfolio of catalog and custom products, providing the flexibility you need from discovery to follow-up studies. Agilent’s custom solutions allow you to target your regions of interest using our free web portal SureDesign. Custom solutions are available for DNA and RNA target enrichment.

The GeneJammer Transfection Reagent is a proprietary formulation of novel polyamines ideal for transient or stable transfections in a wide variety of cell types. This transfection reagent is effective in both serum-containing medium and serum-free medium, offering high efficiencies with minimal cytotoxicity.

Hygromycin B is an antibiotic that kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis.

The LipoTAXI mammalian transfection reagent contains a unique, low-toxicity lipid formulation that has been tested with over 30 cell lines and has been shown to achieve high efficiency transfections with a wide variety of cells. Compared to CaPO4/DEAE-mediated transfection, it provides a 10-fold increase in transient transfection efficiency in many cell lines. This transfection reagent may be used with both adherent cells and…

The MBS Mammalian Transfection kit can increase your transfection efficiencies up to 100-fold. Cells are incubated with CaPO 4 /DNA coprecipitate for only 3 hours, versus 6 to 12 hours with traditional CaPO 4 methods. Additionally, cells can be assayed 12 to 24 hours post-transfection instead of the usual 48 to 72 hours.  

The AAV Helper-Free System eliminates the requirement for wild-type adenovirus co-infection from both AAV vector production and AAV stock titering steps, making this system entirely helper virus-free and safer. This system works with a broad range of hosts and infects both dividing and non-dividing cells.

The AdEasy system saves you a month of work over traditional methods by producing the recombinant adenoviral plasmid by homologous recombination in E. coli. The AdEasy XL system includes BJ5183 cells pre-transformed with the pAdEasy-1 plasmid, this feature dramatically decreases background caused by the non-recombinant shuttle plasmid.

The AdEasy Virus Purification Kit allows the purification and concentration of Adenovirus (from Ad5 strains) with Sartobind ® syringe filters containing an ion exchange membrane adsorber that selectively binds adenoviral particles. Once bound, viral particles can be further purified by washing away nonspecifically-bound proteins before elution.

The pESC vectors are a series of epitope-tagging vectors for expression of eukaryotic genes in the yeast S. cerevisiae.  Each vector contains GAL1 and GAL10 yeast promoters in opposing orientations. With these vectors you can introduce one or two cloned genes into a yeast host strain under the control of an inducible promoter.

Bond Elut 96 Square-well Plates are specially designed to offer superior cleanliness, flow reproducibility, and reliability, ensuring trouble-free, high throughput operation. Conversion of cartridge-based methods to an automation-friendly 96-well plate format has never been easier or faster.

GC/MS Test and Performance Samples Agilent J&W GC Column Test StandardsLC and LC/MS Standards GPC/SEC and GFC Calibration Standards Amino Acids Standards and Reagents CE Standards and Reagents ICP-MS Standards UV-Vis Standards and Reagents Application Specific Standards Residual Solvent Standards SampliQ QuEChERS Standards GC Instrument Evaluation Analyzer Kit Standards GC Instrument Installation and Calibration Standards

The ion source operates by electron ionization (EI) or chemical ionization (CI). The sample enters the ion source from the GC/MSD interface. Electrons emitted by a filament enter the ionization chamber, guided by a magnetic field. The high-energy electrons interact with the sample molecules, ionizing and fragmenting them. The positive voltage on the repeller pushes the positive ions into the lens stack, where they pass throug…

Prevent unknown peaks from impacting your results   Agilent MS Analyzed Vial Kits end the need to pre-test or to rerun samples due to unexpected peaks. Eliminating vials as a source of contamination translates into confidence that your results are accurate and reliable. All MS Analyzed Vials Kits include a Certificate of Analysis that contains true lot-specific and fully traceable LC/MS and GC/MS signal traces as well as criti…

The Cary 5000 is a high-performance UV-Vis and NIR spectrophotometer with superb photometric performance in the 175–3300 nm range. Using a PbSmart detector, the Cary 5000 extends its NIR range to 3300 nm making it a powerful tool for materials science research. The Cary WinUV software, a modular Windows-based software, makes it easy to perform powerful analysis and control a number of optional accessories.

Agilent has discontinued the Cary 300 UV-Vis.

Cary WinUV dissolution software supports both Agilent multicell and fiber optic online UV dissolution systems. The software generates accurate and reliable data and accommodates a wide variety of dissolution samples and methods. Analysts can easily customize final reports with a complete summary of the data acquisition using comparison and statistical evaluation tools, data tables and dissolution profiles.

The worlds fastest and most sensitive CCD detector           The Eos CCD is the fastest and most sensitive CCD detector for X-ray diffraction from Agilent or any manufacturer. With an active area of 92 mm diagonal and a gain of 330 e-/X-ray (Mo) the Eos is the highest sensitivity CCD detector available today. It is ideal for the most challenging experiments in small molecule crystallography, providing data collections faster…

Our Absolutely mRNA Purification Kit produces high yields of pure mRNA using a swift 20-minute protocol. This kit includes customized oligo-dT magnetic particles that exclusively bind mRNA to maximize yield and quality, and minimize rRNA contamination.

Agilent’s Absolutely RNA Product portfolio makes RNA purification from tissue and cell samples easy and fast. Absolutely RNA kits include all the reagents you need for DNA-free total RNA, and miRNA isolation with no additional purchase of DNase required. No heating, no long centrifugation, and no repurification is required. Each absolutely RNA purification kit has been optimized for a specific range of sample sizes and elution…

Agilent’s Absolutely RNA Product portfolio makes RNA purification from tissue and cell samples easy and fast. Absolutely RNA kits include all the reagents you need for DNA-free total RNA, and miRNA isolation with no additional purchase of DNase required. No heating, no long centrifugation, and no repurification is required. Each absolutely RNA purification kit has been optimized for a specific range of sample sizes and elutio…

Agilent’s Absolutely RNA Product portfolio makes RNA purification from tissue and cell samples easy and fast. Absolutely RNA kits include all the reagents you need for DNA-free total RNA, and miRNA isolation with no additional purchase of DNase required. No heating, no long centrifugation, and no repurification is required. Each absolutely RNA purification kit has been optimized for a specific range of sample sizes and elutio…