Products & ReviewLife Sciences
Phenylmethanesulfonyl fluoride
≥98.5% (GC)
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Description
Inhibits serine proteases such as trypsin and chymotrypsin. Also inhibits cysteine proteases (reversible by reduced thiols) and mammalian acetylcholinesterase. Not as effective or as toxic as DFP. Effective concentration 0.1-1 mM. Half-life = 1 hr. at pH 7.5.
Phenylmethanesulfonyl fluoride has been used in following applications:
- cell fractionation.
- used as a supplement in nuclear protein extraction.
- inhibitor of cholesterol esterase (CE) and pseudocholinesterase (PCE).
- used for the collection of blood prior to centrifugation to quantify plasma ANP levels.
