Fc Receptors
Fc receptors are transmembrane proteins typically classified based on the class of antibody they recognize.
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The Fc receptors are transmembrane proteins typically classified based on the class of antibody they recognize. For instance, Fc gamma receptors bind IgG, Fc epsilon Receptors bind IgE and FcR alpha binds IgA and IgM. Fc receptors are expressed by a range of immune cell types where they bind the Fc region of antibodies and modulate immune-related functions such as phagocytosis, cytolytic activity, cellular activation, and the half-life of circulating antibodies. Fc receptors are important intermediaries between the cells expressing them and antibody antigen complexes that trigger these immune responses. Because of this role, an understanding of Fc receptor function is crucial for those developing immunotherapeutic antibodies.
Fc epsilon Receptors
- CD23/Fc epsilon RII
- Fc epsilon RI alpha
- Fc epsilon RI beta/MS4A2
Fc gamma Receptors
- Fc gamma RIB/CD64b
- Fc gamma RIII (CD16)
- Fc gamma RI/CD64
- Fc gamma RII/CD32
- Fc gamma RII/RIII (CD32/CD16)
- Fc gamma RIIA/CD32a
- Fc gamma RIIB/CD32b
- Fc gamma RIIB/C (CD32b/c)
- Fc gamma RIIC/CD32c
- Fc gamma RIIIA/CD16a
- Fc gamma RIIIB/CD16b
- FcgR4/CD16-2
Fc Receptor Homologs (FcRH)
- FCRL1/FcRH1
- FCRL2/FcRH2
- FCRL3/FcRH3
- FCRL4/FcRH4
- FCRL5/FcRH5
- FCRL5/FCRL3
- FCRL6/FcRH6
- FCRLA
- FCRLB/FCRY
Other Fc Receptors
- Fc alpha/mu R
- Fc mu R/FAIM3
- FCAR/CD89
- FCRN
