DNA Analysis ScreenTape
DNA ScreenTape analysis provides a fast, automated, and flexible DNA electrophoresis solution for sample quality control, e.g in next-generation sequencing workflows. The DNA ScreenTape assays can separate DNA fragments and libraries up to 5000 base pairs in 1-2 minutes/sample.
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DNA ScreenTape analysis provides a fast, automated, and flexible DNA electrophoresis solution for sample quality control, e.g in next-generation sequencing workflows. The DNA ScreenTape assays can separate DNA fragments and libraries up to 5000 base pairs in 1-2 minutes/sample.
Data output yields objective quantitative and purity measurements from only 1 uL of sample. The ready-to use ScreenTape technology makes reproducible DNA sizing and quantification possible.
Assays are compatible with all Agilent TapeStation instruments.
Note: Some products within these assays contain SYBR Green I, which is licensed from Life Technologies Corporation for use in research and development only. SYBR is a registered trademark of Life Technologies Corporation.
Features:
- A broad size range allows analysis of DNA fragments and libraries from 35 to 5,000 base pairs.
- Fast results are obtained, with data delivered in approximately 1 minute per sample.
- Minimal sample consumption is required as only 1 uL of DNA sample is needed.
- DNA sample detection is possible down to 0.1 ng/uL.
- Ready-to-use ScreenTape devices, pre-packaged reagents, and automated data analysis offer an easy to use system with reproducible DNA sizing and quantification results.
- No cross-contamination or sample carryover is caused due to the use of single lanes and individual loading tips.
For Research Use Only. Not for use in diagnostic procedures.
Performance characteristics of the cell-free DNA ScreenTape assay
In this application note, Agilent Technologies discusses the performance of the cell-free DNA ScreenTape assay by evaluating sensitivity, accuracy, and precision of quantification and sizing while exploring the performance of the new quality metric %cfDNA. The performance of the assay was compared on the 4150 and the 4200 TapeStation systems to demonstrate a seamless transition between the two instruments.
Quality control of cell-free DNA samples analyzed with next-generation sequencing
Analysis of cfDNA can introduce challenges due to its low concentration and possible contamination from high-molecular-weight (HMW) DNA, both necessitating reliable quality control. In this application note, Agilent Technologies discusses how to assess the quality of cell-free DNA samples analyzed with next-generation sequencing (NGS). The Agilent TapeStation system is a vital quality control tool in NGS workflows. The TapeStation systems and cell-free DNA ScreenTape assay provide a %cfDNA quality metric for determining the quality of input cfDNA for downstream processes.
Quality matters: Tackling high molecular weight DNA contamination in cell-free DNA for optimal liquid biopsy NGS
Tuesday, June 24, 2025 at 16:00 BST / 17:00 CEST / 11:00 EDT / 08:00 PDT
Cell-free DNA (cfDNA) has become an essential tool in clinical research and serves as valuable biomarker in liquid biopsy applications. However, cfDNA presents a challenge for Next-Generation Sequencing (NGS) workflows due to its low yield, complex fragmentation pattern and potential presence of contaminating high molecular weight (HMW) DNA.
In this webinar, our expert speaker will discuss reliable pre-analytical quality control using the Agilent Cell-free DNA ScreenTape assay and the TapeStation systems, emphasizing their relevance to NGS-based liquid biopsy applications.
Key learning objectives
- Understand the challenges associated with cfDNA extraction and HMW DNA contamination.
- Learn about the impact of HMW DNA on cfDNA quality and NGS results.
- Explore how to ensure pre-analytical quality control of cfDNA samples.
- Discover the unique benefits of the Agilent Cell-free DNA ScreenTape assay for obtaining the full picture of your cfDNA quality.
Who should attend?
NGS and genomics researchers, molecular biologists, researchers in cancer diagnostics and liquid biopsy, and sequencing lab managers and technicians
Certificate of attendance
If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.
For Research Use Only. Not for use in diagnostic procedures. PR7001-4363
