ACQUITY UPLC System
Waters ACQUITY UPLC - Dramatic Improvements in Speed, Sensitivity and Resolution Whether you work in methods development or quality assurance, in drug discovery and development or testing for safety in food supplies, you seek a productivity edge. With the ACQUITY UPLC® System, now you can get more information in a single, short run than you've ever seen with HPLC. Waters ACQUITY UPLC System UltraPerformance LC® (UPLC®) techn…
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Excellent product quality
Method development for Biosimilar samples
Product quality is consistent, and it gives a precise, reproducible and accurate results. Better separation technique for drug samples, and their impurities.
Review Date: 7 Dec 2023 | Waters
I think Waters UPLC is a leader with great reliability
Pharmaceutical
Being a user of Waters UPLC for a decade I can say this instrument is very reliable and meets our needs. The service is exceptional
Review Date: 30 Oct 2023 | Waters
Great results, saving
phamaceutical
Is a good system can be applied to get saving through of transference of methodologies from HPLC to UPLC.
Review Date: 24 Jul 2023 | Waters
Precise robust results with minimal downtime
Pesticide residue analysis
Reproducible and robust
Review Date: 18 Apr 2023 | Waters
Good instrument with space for improvement
Analyse small molecules, such as metabolites, drugs and phytochemicals, etc.
The system delivers good results for experienced practitioners, and we have produced good data and publications from Waters instruments. However, after using ThermoScientific UPLC system and the software, we gradually realized that the Water software and connection are not as smooth as other vendors, e.g. ThermoScientific and Agilent. Another thing is mass spectrometry data file format conversion and downstream analysis, which is not as convenient and competitive as other vendors, e.g. ThermoScientific. Waters can develop a new market on the database or curation, etc, using the large amount of data created by users, rather than limiting itself.
Review Date: 17 Apr 2023 | Waters
Great accuracy and precision
Peptide mapping
Easy to use. Highly accurate and robust with repeatable results. Fully automated, very elaborate and easy to learn software with multiple data generation.
Review Date: 23 Mar 2023 | Waters
Waters ACQUITY UPLC - Dramatic Improvements in Speed, Sensitivity and Resolution
Whether you work in methods development or quality assurance, in drug discovery and development or testing for safety in food supplies, you seek a productivity edge. With the ACQUITY UPLC® System, now you can get more information in a single, short run than you've ever seen with HPLC.
Waters ACQUITY UPLC System
UltraPerformance LC® (UPLC®) technology starts with unique 1.7 μm small-particle chemistries. Chromatographers no longer need to choose between speed and resolution–with UPLC you get both.
Instrument Designed for Chemistry; Chemistry Designed for the Instrument
The ACQUITY UPLC System has been holistically designed to match the performance needs of our innovative column chemistries with robust hardware, easy-to-use software and specialized support services.
- Small, pressure-tolerant particles
- High-pressure fluidic modules
- Minimized system volume
- Negligible carryover
- Reduced cycle times
- Fast response detectors
- Integrated system software and diagnostics
With UPLC you have the ability to work more efficiently with higher speed, sensitivity and resolution at a much wider range of linear velocities, flow rates and backpressures to obtain superior results.
The Waters ACQUITY UPLC System's high-pressure fluidics optimizes flow rates to make the most of small particle technology. The ACQUITY UPLC System's sample-handling design is designed to ensure exceptionally low carryover and reduced cycle time. And when interfaced with the Sample Organizer, it increases unattended sample capacity by ten times.
High-speed detectors, both optical and mass, contribute to increased sensitivity and help manage the heightened speed and resolution requirements of UPLC.
ACQUITY UPLC Systems are easily controlled, diagnosed, and monitored via a graphical system console interface. The console offers:
- Quick and easy access to critical instrument parameters
- Simple system start-up, elegant system status monitoring and predictive performance indicators to ensure maximum productivity
- Data management capabilities that are supported by both MassLynx™ and Empower™ software
- The ACQUITY UPLC System is also supported by Intelligent Device Management technology with our Connections® INSIGHT™ service, providing instrument diagnostics.
Brochures
Waters chromatography solutions
In this brochure, Waters™ chromatography solutions are presented as critical components for achieving reliable, consistent, and defensible data in a variety of lab scenarios, addressing key issues such as spec compliance, safety validation, understanding diseases, and identifying effective treatments. Waters provides a comprehensive portfolio that helps laboratories produce quality data and prepares them for future opportunities, ensuring that results are accurate and compliant with the latest guidelines. Waters Chromatography Solutions are highlighted as a comprehensive and adaptable suite of tools and systems that support critical laboratory analyses while ensuring compliance, scalability, and reliability.
Waters automation portal solution
In this application note, Waters™ describes how the Automation Portal enhances laboratory efficiency, throughput and consistency by automating the ACQUITY™ and Arc™ UPLC™, UHPLC, and HPLC Systems. It accomplishes this by streamlining the liquid chromatography (LC) workflow, specifically through the use of robotic arms to manage physical sample transfers into ACQUITY and Arc Sample Managers, thus reducing the potential for analyst errors. Waters emphasizes the Portal's versatility, as it can work with scheduling software for managing laboratory tasks and can integrate with different lab environments and preferred integration partners.
Evaluation of the performance of a total workflow approach for the analysis of perand polyfluoroalkyl substances (PFAS) in fish, using an interlaboratory study
Due to rising concerns about the long-term impacts of per- and polyfluoroalkyl substances (PFAS) on human health, many agencies across the globe have been studying the occurrence of PFAS in food. Waters™ previously developed a method for the determination of PFAS in complex food commodities such as fish, meat, edible offal, and eggs which requires a comprehensive sample extraction and clean-up. This application brief shows the successful evaluation of the performance of this method by interlaboratory study. It is based upon an alkaline extraction, sample clean-up using Oasis™ WAX for PFAS Analysis SPE cartridge and determination using ACQUITY™ UPLC™ System fitted with the PFAS Analysis Kit, Isolator Column and Xevo™ TQ-XS Tandem Quadrupole Mass Spectrometer. A reference material of fish containing PFHxS, PFOS, PFOA, and PFNA was sent to seven Waters laboratories, along with standard solutions containing native PFAS compounds and isotopically labelled analogues. For the four PFAS analytes, trueness of the method was determined to be within the range of 102 to 121%. Repeatability within laboratories was <20% and between laboratory reproducibility ≤30%.
Expert tips to mastering polar analyte separation
Monday, November 3, at 16:00 GMT | 17:00 CET | 11:00 EST | 08:00 PST
Many chromatographers face challenges with polar analyte separation, due to their strong interactions with the stationary phase or poor retention in reversed-phase systems. These challenges often result in suboptimal resolution, peak tailing, or co-elution, often leading to time-consuming re-analysis and column chemistry adjustments.
Join Dr. Chris Collins, Waters Corporation, as he reveals the mechanisms behind polar analyte retention and guides you in how to select the perfect column for seamless separations.
Key learning objectives:
- Understand polar compound retention in reversed-phase HPLC and explore mixed-mode and HILIC alternatives.
- Explore the underlying principles and challenges of retaining and separating polar analytes.
Who should attend?
- Chromatographers who need support in retaining and separating polar analytes in the pharmaceutical, environmental and material science industries.
Certificate of attendance
If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.
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The announcement at Pittcon 2024 highlights the integration of essential instruments for large molecule characterization
The pursuit of the perfect HPLC column: Reflecting on 50 years of innovation
Dr. Thomas H. Walter, of Waters Corporation, looks back at the trials, tribulations, and triumphs that paved the way to today’s advanced separation technologies
