ACQUITY UPLC Oligonucleotide BEH C18 Columns
Exceptional Resolution of Oligonucleotide Mixtures
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Great separation but life span is almost nothing (less than 5 injections)
DNA/RNA phosphoramidite and Oligonucleotide
The UHPLC column has not even lasted for more than 5 injections and gives high back pressure. My team is changing the column almost every day to analyze the samples. Ending in a lot of cost to the company. Great separation during analysis but the life of the column is nothing (less than 5 injections).
Review Date: 18 Sept 2024 | Waters
ACQUITY UPLC Oligonucleotide C18, 1.7 μm Columns are well suited for the analysis of detritylated oligonucleotides using ion-pair, reversed-phase chromatography.
Rapid analysis of synthetic mRNA cap structure using ion-pairing RPLC with the BioAccord LC-MS System
This application note demonstrates a rapid LC-MS method applicable to evaluating the extent of 5’ capping of synthetic mRNA, an important critical quality attribute (CQA) for synthetic mRNAs, using an ACQUITY Premier Oligonucleotide BEH C18 Column couple with a BioAccord LC-MS System.
Improved chromatographic analysis of oligonucleotides with ACQUITY Premier Oligonucleotide BEH C18 Columns
This application note illustrates sources of oligonucleotide loss due to adsorption on metallic column hardware (frits). Solutions, columns, and best practices for improved oligonucleotide analysis are provided.
