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Wyatt Technology will showcase miniDAWN TREOS Multi-Angle Light Scattering Detector at Pittcon

21 Mar 2013
Sarah Thomas
Associate Editor

Product news

Wyatt Technology will display its miniDAWN™ TREOS® Multi-Angle Light Scattering (MALS) Detector, at Pittcon 2013, Philadelphia, PA. The TREOS represents a major advancement in the sensitivity and dynamic range in the MALS measurement of molar mass and size for smaller macromolecules.

Whether in-line with chromatographic separation for analysis of distributions, or in stop-flow mode for characterizing interactions, the latest model provides over twice the signal to noise ratio and 100x the dynamic range of the previous generation of Wyatt’s miniDAWN instruments, allowing the measurement of low-molecular weight proteins, peptides or carbohydrates at lower concentrations than ever before.

Each analog signal (one for each of the three angles) is processed by its own Digital Signal Processing (DSP) integrated circuit with 24-bit digital conversion for extremely high signal resolution. In addition, four auxiliary analog inputs (with their own DSP circuits) are available for interfacing to external detectors, such as DRI, UV, PDA, etc. The TREOS also records the temperature, laser power, and forward monitor signal – a valuable “extra” for studying samples that absorb light.

Optional features may be added such as the embedded COMET™ system, which automatically cleans the flow cell in situ. Just press a button, or schedule cleaning as part of an ASTRA® sample set. This insures that your system produces the same high quality data day after day, with NO downtime. The embedded WyattQELS™ allows simultaneous online measurement of hydrodynamic radius. This improves the resolution of the size distribution measurements by over an order of magnitude compared to batch QELS.

The miniDAWN TREOS can work seamlessly with all other Wyatt instruments, such as the ViscoStar® differential bridge viscometer, via the network or USB interfaces. It has the capability of taking signals from a variety of third party instruments, such as UV absorption, DRI, IR absorption, evaporative light scattering or photodiode array detectors.

The team at Wyatt Technology, the inventors of the world’s first MALS instruments, has several hundred cumulative years of experience in the development and manufacturing of light scattering equipment. The miniDAWN TREOS represents the culmination of this light scattering design experience, providing absolute measurements for results of the highest accuracy for use in the biotechnology, chemical, petrochemical and pharmaceutical industries.

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Size Exclusion ChromatographySize exclusion chromatography (SEC) is a liquid chromatographic technique used to separate and identify molecules based on their size, including polymers, proteins, nanoparticles & nucleic acid. SEC is further subdivided into gel filtration chromatography (GFC) and gel permeation chromatography (GPC) when an aqueous or organic mobile phase is used respectively. HPLC-based SEC systems and columns are available for analytical separation alongside SEC spin columns or filters to prep samples for many protocols. Find the best size exclusion chromatography equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Protein BiologyThe analysis of protein expression, identity and function is vital for many areas of life science research and drug discovery. Some of the most commonly used techniques in protein analysis include Western blotting, electrophoresis and mass spectrometry.PittconPittcon is one of the largest conferences and exhibitions dedicated to laboratory science. It brings together professionals and innovators in analytical chemistry, physics, and biology, offering a platform to explore the latest scientific tools and technologies. From cutting-edge laboratory instruments to emerging research trends, Pittcon is a must-attend event for professionals in research and development. Field Flow Fractionation

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