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What’s New in Biopharmaceutical Research?

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Discover the latest technologies advancing biopharmaceutical analysis

26 Feb 2016
Alex Waite
Editorial Assistant

Editorial article

Download methods and watch videos about the latest technologies for biopharmaceutical analysis

Discover the new technologies to improve your biopharmaceutical analysis workflow with the latest application notes, videos and articles on SelectScience®.

1. Editorial Article: Biopharmaceutical Method Transfer in Regulated Environments

SelectScience® spoke to Kevin McCowen, Associate Scientist at CMO Ajinomoto Althea, Inc., about how the Thermo Scientific™ Vanquish™ UHPLC System is enabling novel solutions to challenging problems. Read more >>

2. Application Note: Liquid Handling: Become a Pipetting Expert

Pipetting like a pro can be more complex than it seems. Stay on top of your most difficult pipetting tasks and have consistent and reproducible results with these tips and tricks from Eppendorf. Download the application note>>

3. Application Note: A Universal LB-MSIA Workflow using Freedom EVO Platform for the Quantitative Analysis of Intact Therapeutic Antibodies of Different Allotype Subclasses

Discover the effectiveness of Thermo Scientific™ enhanced capacity MSIA™ Streptavidin EVO Microcolumns from Thermo Fisher Scientific for quantitatively analyzing therapeutic mAbs of different allotype subclasses. Download the application note>>

4. Video: New Shimadzu LCMS-8060 Triple Quadrupole Mass Spectrometer Launched

Shimadzu’s LCMS-8060 pushes the limits of LC/MS/MS quantitation, detecting substances at ultra-trace levels in complex matrices and at the smallest sample concentrations. Watch the video>>

5. Product: Easy and Rapid Analysis of Protein Stability using the Prometheus NT.48

The Prometheus NT.48 from NanoTemper Technologies is based on advanced Differential Scanning Fluorimetry technology and measures protein stability with ultra-high resolution and easy sample handling. Read more>>

6. Application Note: Dye - and Probe-based qPCR – Using the 0.5 to 20 µL Liquidator™ 96 from Rainin

qPCR is a common technique for detecting and quantifying nucleic acid templates in complex samples. Discover how Rainin’s Liquidator™ 96 pipetting system facilitates qPCR in this download. Download the application note>>

7. Video: VARIO® Vacuum Chemistry Pump PC 3001 VARIOpro

Pump operation only when required — the VARIO® chemistry pumping unit from VACUUBRAND optimizes vacuum conditions automatically and precisely, saving energy and reducing maintenance. Watch the video>>

Do you use any of the products in this article? Is there a product you couldn't do without? Share your experiences with our worldwide community and write a review today.

Discover more new technologies and methods on our Biopharmaceuticals Special Feature Page.

Image: science photo/Shutterstock

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MSIA™ Microcolumns for the Freedom EVO Platform

Thermo Fisher Scientific

Next generation large molecule bioanalysis made easier by combining the Thermo Scientific™ innovative MSIA™ technology with Tecan advanced, robust and easy-to-use liquid handling. MSIA affinity microcolumns, designed for Freedom EVO platform (MCA 96 head), provide innovative enablement in the areas ranging from bioanalysis of therapeutic mAbs, antibody-drug conjugates (ADC), biotransformation [in-vivo modifications, drug-antibody ratio (DAR)], preclinical and clinical drug trials (PKPD, DMPK, and ADME) to biomarker and proteins analysis. This unique solution is designed to deliver the accuracy, reliability and automation you need to be successful.   Features: Robust Automation:  Simply program the Freedom EVO to elute the analyte from complex biological samples and let the automated platform carry the load. Highly sensitive: Analyze proteins of interest down to femtomole level. Enhanced characteristics:  Detects multiple protein variants for qualitative and quantitative bioanalysis in a single assay. Contaminant-free: proprietary molecular trapping microcolumn technology prevents matrix injection that would impact LC-MS function. High signal-to-noise ratio: Innovative sample interface technology reduces matrix loss, reagent carryover and non-specific binding. Time Savings: Microfluidic channels drive kinetic interactions significantly decreasing incubation time required to process the samples, while the MCA 96 head enables parallel processing of 96 samples. Reproducible: Consistent performance for assay reproducibility. Preserving samples: Small sample volumes (as low as 10μL) and a reduced requirement for repeating experiments. MSIA Streptavidin EVO microcolumns provide end user flexibility to analyze their specific targets of interest.

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Eppendorf Research® pro Single and Multi-channel pipettes

Eppendorf

The new electronic pipette Research pro is ideal for all liquid handling jobs in the lab.The clear arrangement of buttons for all operating tasks, the easy-to-follow display and the overall design of the pipette are the product of our original aim of developing an ergonomically outstanding pipette which is ideal for all applications. Work in the lab is now so much easier thanks to various different dispensing techniques, including Pipetting, Dispensing, Reverse Pipetting and Diluting.Simple functions of the new Eppendorf Research® pro, such as Pipetting and Dispensing, are executed as per manual pipettes, which enables the pipettes to be used intuitively without any adverse effect on the variety of functions (programs).The entire spectrum of functions of the single-channel pipette is also available with the multi-channel version, which means that both models can be used without any additional training required.

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.PCR and Thermal CyclingPolymerase chain reaction (PCR) kits and thermal cyclers are used for the in vitro amplification of DNA permitting subsequent analysis and experimental procedures. Explore a range of high-quality polymerase, primers and nucleotides or simplify your workflow with a PCR mastermix. Find reverse transcription PCR (RT-PCR) and cDNA synthesis kits for RNA products and libraries. Quantitatively measure the amplification of DNA with real-time PCR (qPCR) and droplet digital PCR (ddPCR) kits and systems, and discover automated PCR setup solutions to increase throughput. Alternative DNA amplification methods also include recombinase polymerase amplification (RPA) kits. Find the best PCR kits and thermal cyclers and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Pipettes and DispensersPipettes and dispensers are essential lab equipment used to dispense measured volumes of liquid accurately. Explore a range of manual and electronic pipettes, including single and multichannel, serological and volumetric pipettes, as well as a range of pipette tips. Bottle-top dispensers are also available for simple and fast solvent dispensing. Find the best pipettes & dispensers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Labware and Lab SuppliesLabware and lab supplies include various forms of glassware, plasticware, reagents and personal protective equipment (PPE) and are used across all scientific laboratories, enabling daily tasks to be performed. Explore a range of flasks and beakers, petri dishes, carboys and storage bottles. Labware such as condensers, desiccators and burettes are also available for more specific tasks. Find the best labware and lab supplies in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Sample ManagementSample management systems include sample storage devices such as freezers and plate storers, sample environment enclosures and sample organization, retrieval and sorter systems. Useful system features include high-throughput, automation, robotic arms, automated liquid handling and associated database systems. Accessories in sample management include barcode scanners, heat sealers and tubes.Medicinal ChemistryMedicinal chemistry is a broad discipline encompassing the design, identification, synthesis and development of chemicals in drug discovery. It includes a number of techniques covering structural biology, synthetic chemistry and molecular biology. Technologies used in medicinal chemistry include ADME, lab-on-a-chip, high content screening and assay assembly.Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Robotic InstrumentsRobotic instruments can be used for high-throughput automation of many lab processes. Such processes use instruments for assays like cell based assays and ELISA, for sample preparation like shakers, centrifuges and incubators, and for analysis such as sequencing and western blot analyzers. Useful features of robotic instruments include speed, reproducibility, barcode readers, software and automation.Automated Liquid HandlingAutomated liquid handling equipment is used to mix, dilute and dispense allotted volumes of liquid into microplates and other vessels automatically. The robotic, liquid handling arms can dispense from single channel to 3456 multichannel as well as operate nanoliter dispensing, enabling high throughput of samples. Find the best automated liquid handlers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Drug DeliveryDrug Delivery refers to dosage form, route of administration, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. Drug delivery is often approached via the biopharmaceutical or small molecule drug's formulation, but it may also involve medical devices or drug-device combination products. Considerations include instrumentation, software and services.

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