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Waters Presents Advanced Technologies for Cancer Metabolism Researchers at AACR
Booth #3307
27 Mar 2017
Lois Manton-O'Byrne, PhD
Executive Editor
Product news
Waters Corporation will be showcasing a number of advanced technologies that biomedical researchers need to characterize and help better understand cancer metabolism. At booth #3307, the company will provide details about their analytical solutions for omics discovery, biomarker translation, molecular visualization, and the analysis of antibody drug conjugates.
In addition, Waters will be presenting four posters, two jointly with key collaborators, on molecular visualization and glycomics.
Poster Presentations
- Automated, high throughput mass spectrometry imaging of serial sections applied to the investigation of tumour heterogeneity in three dimensions, #203, Sunday PM.
- Rapid Detection of Necrosis in Breast Cancer with Ex vivo and In situ Mass Spectrometry Analysis Methods, #741, Sunday PM.
- Ion mobility separation of N-Glycans directly from FFPE colon cancer tissue section in MALDI imaging experiment, #4642, Tuesday PM.
- New Technologies to Probe the Systems Glycobiology of Cancer, #5544, Wednesday AM.
Waters’ Molecular Visualization tools measure the spatial distribution of molecules, without the need for labelled probes, and can maximize information from tissue samples to elucidate morphology, biomarkers, drugs and metabolites. They will also feature protein and metabolite biomarker verification and validation tools that can accelerate cancer research and minimize analytical variability for consistent, reproducible results that can accelerate decision timelines.
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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer.
AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :MetabolomicsMetabolomics is the study of small metabolites (the intermediates and products of metabolism). It involves the identification and quantification of cellular metabolites using analytical technologies such as GC, HPLC, NMR, and LC/MS.Cancer ResearchCancer research aims to understand the mechanisms of cancer development and progression to improve prevention, diagnosis, and treatment. From molecular biology to clinical trials, research spans a wide range of disciplines, including immunotherapy, targeted therapies, and drug discovery. Explore the best cancer research products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Antibody Drug ConjugatesBiomedicalDrug MetabolismDrug metabolism is the enzymatic conversion within the body of pharmaceutical substances into other chemical compounds. The primary site for drug metabolism is the liver.AACR 2017Biomarker DiscoveryClinical biomarkers refer to substances related to known medical conditions that can be accurately measured <i>in vitro</i>. Biomarkers can be used to diagnose presence of a disease and indicate disease severity. The discovery of new biomarkers is incredibly valuable in the field of diagnostics.