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Waters Corporation Brings High Definition to Proteomics at HUPO 2007

Waters
9 Oct 2007
Greg Smith
Analyst / Analytical Chemist

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At the Human Proteome Organization’s 6th Annual World Congress, Waters Corporation is showcasing several technologies expected to give proteomics researchers new insights into the workings of the human proteome.

The Waters® Synapt HDMS™ System is intended for researchers working at the limits of conventional mass spectrometry (MS) and who need to further characterize and define their samples. The Synapt HDMS system is the first mass spectrometer of its kind to employ high efficiency ion-mobility based measurements and separations and specialized software to enable the analysis of sample ions differentiated by size, shape and charge as well as mass. This additional dimension of separations fidelity leads to improved specificity and sample definition, meaning scientists can extract more information about their samples including the detection of previously unseen constituents.

The Waters® IdentityE High Definition Proteomics™ System is an UltraPerformance LC® (UPLC®)/High-Bandwidth Mass Spectrometry (MSE) system solution designed for highly-confident protein identification and to meet stringent requirements. The Waters IdentityE High Definition Proteomics System catalogs complex protein digest mixtures containing tens of thousands of peptides. The system features a Waters nanoACQUITY® UltraPerformance LC (UPLC) System for high chromatographic peak capacity and retention time reproducibility, together with an electrospray tandem mass spectrometer (Waters Q-Tof Premier™ or Waters Synapt HDMS) for high dynamic mass resolution and consistent over-sampling of complex protein digests – two hallmarks of high definition proteomics.

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.

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