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Waters Corporation and Dotmatics Limited to Collaborate

Dotmatics Limited
18 Jun 2007

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Waters Corporation and Dotmatics Limited today announced an agreement to develop integrated advanced structure elucidation software to complement Waters time-of-flight (Tof) mass spectrometers and the Waters® Synapt™ and MALDI Synapt High Definition Mass Spectrometry ™ (HDMS) Systems. The agreement will focus on developing a fully-integrated solution for structural elucidation of small molecules based on Dotmatics and Waters MassLynx™ MetaboLynx™ Application Manager software.

The new software will give scientists the ability to comprehensively identify ion fragments by more accurately interrogating small molecule MS/MS, or MS E, data for discovery, development, and manufacturing analyses in the chemical and pharmaceutical industries.

"We are pleased to provide researchers with a fully integrated software package which is compatible with our innovative LC/MS/MS and LC/MS E data acquisition strategies that will allow scientists to interrogate fragmentation rich spectra and reduce the bottleneck in deciphering important molecular structures. The combination of Synapt HDMS System and this important collaboration will provide researchers with advanced tools for small molecule profiling," said Dr. Tim Riley, Vice-President and Managing Director – Pharmaceutical Business Operations, Waters Division.

“We look forward to a fruitful collaboration with Waters Corporation” said Alastair Hill, Director and CTO at Dotmatics. ”This agreement puts in place a framework to deliver novel software algorithms within the Waters MassLynx software platform which promises to result in huge time savings for scientists.”

The Dotmatics structural elucidation software is now available from Waters Corporation as an option for Waters MassLynx software.

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Data AnalysisData analysis hardware and software is available to make data processing straight-forward yet powerful. Data software can be used for math and stats, technical graphing and image analysis. In addition, software is available for specific data analysis of electrophoresis, densitometry, ELISA and DNA sequencing.Chem / BioinformaticsCheminformatics and bioinformatics are computational techniques used in chemistry and biology, respectively, for data acquisition, processing and storage. Cheminformatics focuses on compound information, whereas bioinformatics is mainly applied to analysis and modeling of genomics, genetic and sequencing information. Hardware and software is available for data acquisition, analysis, management and storage.Molecular Recognition SoftwareMolecular recognition software is widely used to analyze DNA, RNA, proteins and chemicals. The software can be useful for graphical viewing, comparative analyses, high-throughput screening, genomics, proteomics and phylogenetics. Molecular recognition software uses bioinformatics tools and analyses such as BLAST searches and generates structural predictions, 3D structures and sequencing information.MALDI-TOF MSMALDI-TOF mass spectrometers (matrix-assisted laser desorption/ionization time-of-flight) are used for the mass analysis of large molecules, including proteins, DNA, polymers and other macromolecules due to its relatively soft ionization, reducing fragmentation whilst allowing fast data acquisition. Tandem mass analyzers such as TOF/TOF systems can be used to increase resolution and sensitivity of your analysis. Find the best MALDI-TOF products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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Waters Corporation and Dotmatics Limited to Collaborate