ViaLogy Corp. Reveals Preliminary Results for GC-MS: Improves Sensitivity Approximately 50 Times

ViaLogy Corp., inventor of QRI™ active signal processing software, today announced that Dr. Thomas George, in association with other ViaLogy scientists, will present a new mathematical model and algorithms at the upcoming conference of the American Society of Mass Spectrometry, that has the potential of extending the sensitivity of most MS instruments. The subject of the poster session will be “Extending the Low Analyte concentration Limit of Quantitation for GC-MS Using a Novel Maximum Aposteriori Probability (MAP) Algorithm”.

The presentation of the postersession, number 141, will take place on Wednesday morning, May 31, 2006 at the ASMS Conference in Seattle Washington.

There has been considerable interest recently in extending the ability of routine MS instruments to routinely measure lower analyte concentrations. At the lower limit of detection, the analysis problems include the limited transmission efficiency of analyte ions in a background of excited neutral carrier gas species where the analyte signal is less than the background signal. The new MAP model and associated algorithm from ViaLogy uses discrete-event probability estimators that have been demonstrated under R&D research conditions to extend the current single quadrupole GC-MS Lower Limit of Quantitation by about 50 times.

“We applied the first of two major steps in our QRI software process, which is similar to military radar hardware, to quadrupole MS data files and we were pleasantly surprised to see very significant improvement. We expect to see further improvements as we complete the next step. Users of tens of thousands of mass spectrometers will benefit from this innovation,” said Bud Bromley, VP business development, sales and marketing at ViaLogy.