Ventana to Partner with Incyte on the Development of Companion Diagnostic Tests

5 Nov 2013
Sonia Nicholas
Managing Editor and Clinical Lead

Product news

Ventana Medical Systems, Inc. (Ventana), a member of theRoche Group, today announced that it has entered into an agreement with Incyte Corporation to collaborate on the development of companion diagnostic tests for Incyte's oncology drug programs, beginning with the Incyte IDO1 inhibitor program. As part of the agreement, Ventana will support Incyte's personalized medicine healthcare strategies for cancer drug development using its vast expertise in companion diagnostics, immunohistochemistry technology platforms, and worldwide customer support network.

Companion Diagnostics, meaning tests paired with drug therapies, help physicians identify those patients with specific biomarkers who may respond to certain types of targeted drug treatment. Incorporating a companion diagnostic strategy into a drug development program may expedite the approval process and help generate better drugs with improved safety profiles for patients.

"With the advancement of INCB24360 into multiple Phase 2 studies, our first-in-class IDO1 inhibitor program was a logical place to begin to incorporate potential companion diagnostics. We chose to partner with Ventana based on their strong scientific knowledge and development expertise in this area," stated Victor Sandor, MD, CM, Incyte's Group Vice President, Clinical Development.

"We are pleased that Incyte shares our passion of enabling personalized medicine for cancer patients worldwide and look forward to pursuing many successful drug development programs together," says Mara G. Aspinall, President, Ventana Medical Systems, Inc.

In addition to Incyte, Ventana has worked with more than 45 biopharmaceutical partners over the past decade and is currently engaged in more than 150 collaborative projects to develop and commercialize companion diagnostics globally.

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ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Clinical TrialsClinical Trials, an essential part of drug discovery process, assess the safety and effectiveness of a new medication or device in the pharmaceutical industry. Clinical Trials are a phased process (Phase 0, Phase I, Phase II, Phase III and Phase IV) which begins after initial preclinical testing.Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.Companion DiagnosticsCompanion diagnostics are tests, often <i>in vitro</i>, that are used to determine whether a therapeutic product will be safe and effective for use on an individual. They also identify which patients will benefit most from them. Companion diagnostic tests are often developed in conjunction with the pharmaceutical industry.
Ventana to Partner with Incyte on the Development of Companion Diagnostic Tests