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Using advanced high-throughput flow cytometry to accelerate immuno-oncology drug discovery

Sartorius Group

Sartorius Intellicyt addresses challenges such as high cost and purification difficulties and presents possible solutions

18 Nov 2019
Laura Sisman
Administrator / Office Personnel

Industry news

Immuno-oncology, which centers around using the body’s own immune system to fight cancer, is seen as an increasingly significant and effective therapy.

However, although advances in the field have been rapid, challenges remain, such as prohibitive costs and an inability to produce high quantities of purified immune cells.

One especially significant area of active research is to investigate the wide discrepancy between the treatment responses exhibited by different patients.

With more traditional methods proving limited, Sartorius Intellicyt has published an article addressing challenges in the field and exploring how to overcome them using advanced high-throughput flow cytometry.

To find out more download the article here.

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Flow Cytometry / Cell CountingFlow cytometers are used to count, sort and examine multiple characteristics of cells. Other cell analysis equipment includes image cytometers, cell counters, fluorescence-activated cell sorters (FACS), magnetic-activated cell sorters (MACS), and a range of flow cytometry assay kits. Flow cytometers can reveal information on cell viability, cell proliferation, apoptosis and cell cycle progression, as well as identify cell populations and intracellular or cell-surface molecules. Additionally, some flow cytometers, known as FACS, have an additional sorting function after analysis. Cell counters and image cytometers count live and dead cell populations and can also conduct cell proliferation assays. Find the best flow cytometers, cell counters and cell sorters in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Drug DiscoveryDrug discovery is the process of identifying potential new medications, involving stages such as target identification, compound screening, and preclinical development. It relies on cutting-edge technologies like high-throughput screening, artificial intelligence, and molecular modeling to accelerate the identification of drug candidates. Drug discovery plays a pivotal role in developing new therapies for diseases ranging from cancer to rare genetic disorders. Browse our peer-reviewed product directory to find the latest drug discovery technologies, compare options, check customer feedback, and get pricing directly from manufacturers.Flow CytometryImmunophenotyping

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Using advanced high-throughput flow cytometry to accelerate immuno-oncology drug discovery