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Unyvero AMR Atlas to Support Adoption of Rapid DNA Testing for Antibiotic Resistance

Curetis N.V

The Unyvero Platform allows rapid testing for a broad range of pathogens and antibiotic resistance markers associated with life-threatening infections in hospitalized patients

1 Apr 2019
Phillip Atkinson
Administrator / Office Personnel

Product news

Curetis N.V., a developer of next-level molecular diagnostic solutions, has announced that it will introduce its newly developed Unyvero AMR Atlas at the upcoming 29th European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), which will take place in Amsterdam, the Netherlands, on April 13-16, 2019.

The Unyvero AMR Atlas is a knowledge base of genetic antimicrobial resistance markers (AMR) that is specifically designed for Curetis’ Unyvero Application Cartridges. The Unyvero Platform allows rapid testing for a broad range of pathogens and antibiotic resistance markers associated with life-threatening infections in hospitalized patients. The Unyvero AMR Atlas provides Unyvero users with well-structured, marker-centric overviews of the available knowledge on the respective AMR markers featured on the Unyvero Application Cartridges.

The information provided by the Unyvero AMR Atlas includes mechanisms of resistance, antimicrobial drug classes affected by these mechanisms, prevalence of such markers in different bacterial pathogens and, most importantly, the accuracy of the markers in predicting resistance to these drugs. For clinicians, this information is key in considering the significance of the respective resistance markers when determining the optimal therapeutic strategy for patients with life-threatening infections. Thereby, they can realize the full potential of the rapid test results obtained with the Unyvero platform.

The cloud-based Unyvero AMR Atlas has been developed by Curetis’ subsidiary Ares Genetics (Vienna, Austria) and builds on ARESdb, Ares Genetics’ AI-powered reference database on the genetics of antimicrobial resistance. ARESdb currently covers detailed genetic data on more than 35,000 bacterial strains including quantitative data on the resistance phenotype of more than 100 antibiotics. The Unyvero AMR Atlas is initially tailored to Curetis’ Unyvero Pneumonia Applications, which includes HPN and LRT Cartridges for lower respiratory tract infections in Europe and the USA, respectively.

“While rapid syndromic testing holds great promises in improving infectious diseases management, it is not sufficient anymore to only provide information on the causative pathogen but also to test for the resistances already acquired by such pathogens,” said Dr. Achim Plum, Chief Business Officer of the Curetis Group and Managing Director of Ares Genetics. “However, interpreting the presence or absence of genetic resistance markers in the context of clinical decision making is quite complex. With the Unyvero AMR Atlas, the relevant scientific and clinical information on such markers are made available at the fingertips of our Unyvero customers via a well-structured and intuitive user interface. We expect that this will support the wide-spread adoption of such marker in routine clinical settings.”

“With the introduction of the first release of the Unyvero AMR Atlas at ECCMID 2019, we are excited to engage with the clinical microbiology community to demonstrate the benefits of this knowledge base in day-to-day decision making and the feedback will help with further development and enhancement of the platform,” explained Faranak Atrzadeh, Senior Vice President, Scientific Affairs and Marketing at Curetis.

The Unyvero AMR Atlas will be featured at the Curetis booth (#1.65) at ECCMID 2019 in Amsterdam, the Netherlands, on April 13-16, 2019.

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MicrobiologyMicrobiology is the study of microorganisms including protists, prokaryotes, fungi, and, often, viruses. Microorganisms are a useful research tool as genetic vectors and, in immunology, for antibiotic susceptibility testing, cellular biology and genetics. Microorganisms commonly grow readily in incubators with microbial culture media; this can contain chromogenic supplements to differentiate between cell lines. Estimate your culture’s density of microorganisms with colony counters, or screen and select colonies for desirable clones with automated colony pickers. Additionally, equipment is available to monitor environments for the presence of microbes and identify with microbial identification instruments. Find the best microbiology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Clinical MicrobiologyMicrobiology is the study of microorganisms including protists, prokaryotes, fungi, and, often, viruses. Microorganisms are a useful research tool as genetic vectors and, in immunology, for antibiotic susceptibility testing, cellular biology and genetics. Microorganisms commonly grow readily in incubators with microbial culture media; this can contain chromogenic supplements to differentiate between cell lines. Estimate your culture’s density of microorganisms with colony counters, or screen and select colonies for desirable clones with automated colony pickers. Additionally, equipment is available to monitor environments for the presence of microbes and identify with microbial identification instruments. Find the best microbiology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.DNADeoxyribonucleic Acid (DNA) is the main component of chromosomes and the carrier of genetic information of living organisms. Find out here about PCR, NGS, ChIP-Seq, gel imaging, and many other techniques which can be used for the analysis of DNA.AntimicrobialsAntibioticsAntibiotics are substances that kill or inhibit the growth of microorganisms, such as bacteria and fungi. They are essential in the treatment of infections and in preventing disease spread. Explore antibiotics research and diagnostic tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Antibiotic ResistanceAntibiotic resistance poses a significant threat to public health driving innovation and change through antibiotic stewardship efforts. Ongoing research and diagnostic efforts focus on new treatments and detection methods. Explore antibiotic resistance research and diagnostic tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Infectious DiseasesInfectious diseases are caused by pathogens such as bacteria, viruses, and fungi. Effective detection, prevention, and treatment are crucial to control outbreaks and improve public health. Diagnostic tools, vaccines, and antimicrobial treatments are essential components of managing these diseases. Research into emerging pathogens and resistance patterns continues to evolve. Browse our peer-reviewed product directory to find the best diagnostic tools, prevention solutions, and treatment options; compare products, read customer reviews, and get pricing directly from manufacturers.

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Unyvero AMR Atlas to Support Adoption of Rapid DNA Testing for Antibiotic Resistance