Uniqsis announces the FlowSyn Automated Loop Filling system

The exciting new automated product is designed to harness the power of flow chemistry to deliver more compounds faster

21 Jun 2020
Cameron Smith-Craig
Cameron Smith-Craig
Pharma and Applied Sciences Editor

Product news

The FlowSyn Auto-LF is a powerful and highly efficient module for running multiple experiments with multiple reagent inputs under different sets of chemical conditions.

This new product is ideal for robotic synthesis groups looking to generate combinatorial libraries utilizing the power of flow chemistry. Designed to run multiple experiments with multiple reagent inputs (with a choice of 2 or 4 channels) this intelligent simultaneous loop filling and fraction collection system saves valuable time by loading the reagent loops for the next reaction whilst the current run is in progress. Fully integrated wash protocols minimize the risk of cross-contamination.

FlowSyn Auto-LF incorporates an automated liquid handler that can accommodate up to 96 samples. Flow chemistry fractions can be collected either separately on a single rack fraction collector or on a 4-rack collector to further enhance your combinatorial chemistry throughput.

Utilizing Uniqsis's highly intuitive FlowControl software - the FlowSyn Auto-LF displays graphical real-time information (reactor(s) temperature, system, and individual pump pressures for reaction monitoring and data logging as well as flow rate/residence time. Setting up multiple reaction protocols is straightforward utilizing the FlowControl software’s wizard-based approach.

FlowSyn Auto-LF™ is compatible with Uniqsis HotCoil™, ColdCoil™, HotChip™ and PolarBear GSM™ reactors with an operating temperature range of -70°C to 300°C

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FlowSyn Continuous Flow Reactor

Uniqsis Ltd

FlowSyn - Making Flow Chemistry Simple FlowSyn is a fully integrated continuous flow reactor with everything you need to start doing flow chemistry including reaction optimization, synthesis and scale up. To provide maximum flexibility, a wide range of mixer and reactor options are available as well as additional modules for performing multiple experiments, or sub-ambient chemistry. • Ability to perform continuous flow chemistry under microwave-like conditions (up to 260oC). • Perform sub-ambient continuous flow chemistry using the 'Cold Coil'. • Run up to 10 automated sequential experiments with the 'Automated Experiment Package'.A pair of high pressure pumps are used to deliver reagent solutions from either stock bottles or sample injection loops through a 'T'-mixer into the electrically heated flow reactors. Reactions can be heated to 260?C and 150?C in the coil and column reactor modules respectively. Back pressure regulators of up to 1000 psi are used to pressurise the system and thus perform superheating of solvents, allowing the chemist to access'microwave like' conditions with no limitation on scale. FlowSyn is very easy to use with a high resolution user interface. The user is guided through the process for setting up a flow chemistry reaction by inputting parameters for reagent volumes, temperatures and reaction times. The user can choose to collect all of the reaction plug, or only the 'steady state' part. FlowSyn will then equilibrate and run the reaction, and finally flush the system through with solvent. Throughout FlowSyn will monitor the pressure of the system, and shut down if a problem occurs allowing FlowSyn to be safely run unattended.

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Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.Flow Cytometry / Cell CountingFlow cytometers are used to count, sort and examine multiple characteristics of cells. Other cell analysis equipment includes image cytometers, cell counters, fluorescence-activated cell sorters (FACS), magnetic-activated cell sorters (MACS), and a range of flow cytometry assay kits. Flow cytometers can reveal information on cell viability, cell proliferation, apoptosis and cell cycle progression, as well as identify cell populations and intracellular or cell-surface molecules. Additionally, some flow cytometers, known as FACS, have an additional sorting function after analysis. Cell counters and image cytometers count live and dead cell populations and can also conduct cell proliferation assays. Find the best flow cytometers, cell counters and cell sorters in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.Automation Supplies / AccessoriesAutomated accessories and consumables make lab processes fast, efficient and reliable. Useful automation accessories include microplate sealers, label printers and reagent reservoirs.Flow ChemistryFlow chemistry describes a chemical reaction being carried out continuously rather than in a batch process. The reagents are pumped through a pipe and forced together at a mixing junction, where they are allowed to combine until the reaction is stopped.Liquid HandlingLiquid handling involves the precise transfer, mixing, and dispensing of liquids in laboratory settings. It is essential for accurate and consistent results in biological, chemical, and pharmaceutical research. Automated liquid handling systems improve efficiency and reduce human error in sample preparation and analysis. Explore liquid handling tools in our peer-reviewed product directory; compare products, read customer reviews, and get pricing directly from manufacturers.
Uniqsis announces the FlowSyn Automated Loop Filling system