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Ultra-Sensitive Assay Services for Measurement of Low Abundance Biomolecules in Human Serum or Plasma Are Now Available From PBL

PBL InterferonSource
4 Jun 2013

Product news

PBL InterferonSource announces the expansion of its assay services portfolio to include 30 different ultra-sensitive biomolecule assays. Based on an innovative single-molecule counting (SMCI) technology, these services are designed to provide sub-picogram per ml sensitivity for analytes in human serum or plasma. The background reduction methodology of this detection service extends the linear dynamic range to over 4 logs, allowing high levels of biomarker measurement with minimal dilution in many disease states.

“We are proud to add ultra-sensitive cytokine detection services into our offerings to researchers around the world,” said Dr. Thomas Lavoie, Director of Product Research & Development and Assay Services at PBL. “The ability to measure basal levels of cytokines and other biomarkers in the femtogram per ml range will enable far deeper analysis of changes in these biomarkers. This enhanced understanding of various diseases and the effects of treatments will allow earlier project milestone decisions, saving our clients time, money and concern.”

The addition of ultra-sensitive cytokine detection services signifies PBL’s commitment in providing the best service solutions to meet scientists’ assay needs. It complements the company’s single-analyte ELISA, cytokine multiplex ELISA, and cell-based activity assay services that are currently offered in their sample testing and screening catalog.

Initial ultra-sensitive assay services by PBL include detection for cytokines such as human IL-17A, IL-17F, IL-17 A/F heterodimer, IL-6, IL-10, IL-15, TNF-alpha, GLP-1, and biomarkers such as cardiac troponin-I.

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ELISAEnzyme-linked immunosorbent assays (ELISA), also known as enzyme immunoassays (EIA), are used for the detection and quantification of proteins, peptides and antibodies in a sample. ELISA often comes in kit format, with pre-selected antibody pairs to detect specific proteins or biomarkers of diseases such as diabetes and obesity, or cardiovascular and neurological disorders. Detection is made possible with chemiluminescent, fluorescent or colorimetric substrates and detection instruments such as microplate / ELISA readers. Other kits available include: Enzyme-linked immunospot (ELISPOT) assays for the quantification of protein-producing cells and chemiluminescent immunoassays (CLIA) kits. Find the best ELISA kits and products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.HematologyIn Haematology / Hematology, complete blood cell counts (or full blood counts) are obtained using automated blood count analyzers to enumerate blood cell types.  Hematology also encompasses haemostasis and coagulation, thrombophilia and hemophilia, plasma viscosity and ESR analysis, hemoglobinopathies, cell morphology and haematinic measurement.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :CytokinesCytokines are signaling proteins critical for cell communication in the immune system. They regulate inflammation, immune responses, and cell growth. Cytokine research is vital for understanding disease mechanisms and developing therapies. Explore tools for cytokine detection and analysis in our directory.SensitiveHuman PlasmaHuman plasma is the liquid component of blood, which carries blood components - nutrients, hormones, proteins, and waste - throughout the body. Plasma-based studies provide insights into biomarkers, immune responses, and disease mechanisms. Compare plasma handling tools and systems in our peer-reviewed product directory.Human SerumHuman serum is found in blood plasma. The protein is used in a variety of applications including tissue engineering, transplantation and cell therapy.

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Ultra-Sensitive Assay Services for Measurement of Low Abundance Biomolecules in Human Serum or Plasma Are Now Available From PBL