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Ultra-Fast Preparative and Purification Liquid Chromatograph

Shimadzu Corporation
16 Nov 2016
Emily Adam
Publishing / Media

Product news

Shimadzu, one of the world leaders in analytical instrumentation, has released the "Prominence UFPLC" Ultra-Fast Preparative and Purification Liquid Chromatograph, which enables fast recovery of highly purified target compounds from complex samples such as organic synthesis reaction mixtures and natural products.

Conventional workflows utilizing preparative liquid chromatography (Prep LC) yield fractions with significant water content which can take eight hours or more to evaporate and typically cannot be completely removed, resulting in a powder with poor weight purity.

The Prominence UFPLC offers a single automated workflow that utilizes on-line fraction trapping as an alternative to traditional fraction collection, allowing elution of collected compounds in highly volatile organic solvents that can easily be evaporated, resulting in ultrahigh weight purity compounds in about 90 minutes. The Prominence UFPLC greatly improves the efficiency of preparative fraction collection and purification workflows in pharmaceutical, food, chemical and other industries as well as research organizations.

Prep LC is a widely used technique in many research, development and manufacturing applications, including synthesis of new drug compounds, discovery of active components in natural products and as a mechanism to collect large amounts of unknown compounds in foods and drugs for subsequent structural analysis. In 2013, Shimadzu released the "Crude2Pure" Automated Purification/Powderization System, which removed mobile phase contaminants from PrepLC fractions and returned a highly pure and very dry powder with an option to recover that powder as a free base. Prominence UFPLC inherits the breakthrough fraction trapping and purification technology at the core of Crude2Pure and expands on it to provide a comprehensive on-line automated purification process.

Key Features

  • Recover ultrapure compounds from a complex sample in 1.5 hours
  • High purity compounds, optionally recovered as a free base
  • Optimized instrument footprint providing cost-effective solution

With the introduction of Prominence UFPLC, Shimadzu expands its extensive chromatography portfolio to include a comprehensive automated solution for preparative separations, fraction purification and compound powderization, contributing greatly to improved efficiency in any application requiring preparative purification.

Links

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.Preparative ChromatographyPreparative chromatography equipment is used for purification purposes, separating and collecting compounds eluted from a mixture which can then be subsequently used for further purposes. This can be done in large quantities or small. Preparative chromatography systems are usually low to medium pressure liquid chromatographs that are semi-automated. Explore a range of preparative columns and fraction collectors. Find the best preparative chromatography equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.PurificationPurification techniques are essential for isolating compounds of interest from complex mixtures, such as proteins, nucleic acids, and chemicals. These techniques are critical in biochemistry, drug development, and environmental studies. Explore purification systems in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.HPLC Method DevelopmentIt is important to develop and validate HPLC methods in order to identify, quantify or purify compounds of interest in the most efficient way. Effective method development ensures optimization, quality control and cost effectiveness.ChromatographyChromatography is a powerful technique used to separate and analyze components of mixtures based on their chemical properties. It is widely used in fields like biochemistry, pharmaceuticals, and environmental analysis. By exploiting differences in the interaction of substances with a stationary phase and a mobile phase, chromatography enables precise purification and quantification of compounds. Whether you're working with complex biological samples or industrial chemicals, chromatography is essential for obtaining high-quality results. Browse our peer-reviewed product directory to find the best chromatography systems, compare products, read customer reviews, and get pricing directly from manufacturers.

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