Triple Quadrupole MS for Fast Detection Speeds

Shimadzu UK’s new LCMS-8030 Triple Quadrupole Mass Spectrometer makes fast measurement times a reality. Combining scanning speed with the power of triple quadrupole mass spectrometry provides a boost to lab productivity.

The instrument is ideal for researchers performing lots of method development work who are facing the challenge of needing to detect more target analytes with greater sensitivity in hundreds of samples per day. Key applications include food and environmental analysis, drugs of abuse screening as well as materials analysis.

The system offers researchers doing method development the capability to gain more information for less effort. A single injection will provide a full scan, multiple reaction monitoring (MRM) transitions and pos/neg data at the same time to allow matrix effects to be seen more clearly. The LCMS-8030 allows researchers to make quantification and confirmation measurements in a single scan of any compound which is ionized to either a positive or negative ion.

Without reducing sensitivity or resolution, the instrument is capable of performing fast mass spectrum measurement speeds of 15,000 u/sec and fast polarity switching (15msec) to capture information without signal deterioration.

Coupling the LCMS-8030 with Shimadzu’s Nexera UHPLC enables UHPLC performance to be increased by offering users reliable and accurate detection of peaks only one-second wide.

The combination of the LCMS-8030 with Nexera creates a unified platform that provides excellent qualitative and quantitative analysis as well as fast workflows for high-throughput analysis. Unattended, overnight operation is made possible by means of automated optimization of analytical conditions for each quantitative target compound.

Shimadzu UK’s LC/LCMS Business Manager Stuart Phillips, said: “The LCMS-8030 system is ideal for users that have a desire to achieve the maximum return on investment (ROI) and want to produce ‘more information for less effort‘. Once a researcher has developed new methods the LCMS-8030 will allow individual components to be easily be reused, reducing rework and improving productivity. The instrument is also ideal for new users that need to learn software quickly”.

“Being able to scan faster while having the shortest ‘pause and dwell’ times means getting more points across a peak which translates into better quantitative analysis and give users the right answer first time. Many of the LCMS-8030’s features are focused on achieving productivity gains”.