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Tri-Con 2014 – EKF Molecular to Showcase PointMan™ DNA-Enrichment Kits

EKF Diagnostics
10 Feb 2014
Sonia Nicholas
Managing Editor and Clinical Lead

Product news

Ultra-sensitive and highly-specific cancer mutation detection

EKF Diagnostics, the global in vitro diagnostics business, announces that its subsidiary company EKF Molecular Diagnostics is exhibiting its ground-breaking PointMan™ DNA-enrichment technology at Tri-Con 2014 in San Francisco, CA, Booth #417, 10-14th February.

PointMan is a real-time PCR technology that provides reliable and extremely sensitive detection of cancer-related mutations. Fully compatible with industry standard instruments and DNA extraction methods, it is highly specific and efficient in amplifying the target sequence, while simultaneously suppressing amplification of the wild-type. The resulting sample is effectively enriched for the mutation, providing industry-leading sensitivity across a wide variety of sample types, including whole blood.

PointMan’s landmark ability to enrich low-level DNA mutations from whole blood is the focus of an ongoing collaboration between EKF Molecular Diagnostics and the Institute of Life Sciences at Swansea University. Recent preliminary results from a study of samples archived in the Wales Cancer Bank, have demonstrated that PointMan technology could enable non-invasive blood based testing and reduce the need for tumor biopsies for cancer patient mutation status assessment.

Personnel from EKF Molecular Diagnostics will be on hand at Tri-Con 2014 to demonstrate and discuss the effectiveness of EKF Molecular's portfolio of PointMan DNA enrichment kits that detect mutations for cancer biomarkers including: BRAF, KRAS, EGFR, NRAS and JAK2. These genes are associated with skin melanoma, colorectal and lung cancers, as well as myeloma.

The 21st International Molecular Medicine Tri-Conference will focus on Drug Discovery, Genomics, Diagnostics and Information Technology. “Tri-Con 2014 provides an ideal platform to feature our growing range of products and technologies developed to meet an increasing demand for superior sensitivity and specificity in molecular diagnostics,” said Andrew Webb, CEO, EKF Molecular Diagnostics.

For more information on EKF Diagnostics, please click on the ‘request information’ tab below or follow the company website link.

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.PCR and Thermal CyclingPolymerase chain reaction (PCR) kits and thermal cyclers are used for the in vitro amplification of DNA permitting subsequent analysis and experimental procedures. Explore a range of high-quality polymerase, primers and nucleotides or simplify your workflow with a PCR mastermix. Find reverse transcription PCR (RT-PCR) and cDNA synthesis kits for RNA products and libraries. Quantitatively measure the amplification of DNA with real-time PCR (qPCR) and droplet digital PCR (ddPCR) kits and systems, and discover automated PCR setup solutions to increase throughput. Alternative DNA amplification methods also include recombinase polymerase amplification (RPA) kits. Find the best PCR kits and thermal cyclers and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.DNA / RNA Extraction and PurificationPurified DNA and RNA are required for numerous downstream molecular biology applications. Consequently, the importance of high-quality DNA/RNA extraction and purification equipment cannot be underestimated. Many purification kits are available and are typically optimized for nucleic acid type and source, including plasmid DNA, genomic DNA, mRNA, RNA and viral nucleic acid purification kits. Automated extraction and purification of nucleic acids can be implemented with magnetic bead separator instruments or high-throughput purification workstations. Find the best DNA/RNA extraction and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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Tri-Con 2014 – EKF Molecular to Showcase PointMan™ DNA-Enrichment Kits