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Trending in drug discovery: The microbiome, biopharmaceuticals and tuberculosis

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Get up to date on hot topics in the drug discovery community in our latest monthly compilation of content highlights

8 Aug 2019
Holly McHugh
Administrator / Office Personnel

Editorial article

In this drug discovery round-up, we bring you the biggest news stories, our top pick of useful resources to help you optimize your workflow and insightful video interviews with leading scientists. From microbiome discoveries and biopharmaceutical developments to tackling tuberculosis and SLAS Europe 2019 highlights, find all this and much more!

SLAS Europe 2019 video highlights

After a witnessing the latest innovations changing the future of drug discovery at SLAS Europe 2019, we’ve put together a video playlist featuring key technologies and research highlighted during the conference, including solutions for automation, assay development, high-throughput screening and an interview with SLAS CEO Vicki Loise on the success of this year’s meeting, plus much more! Catch up here in case you missed them.

Show highlights >>


Next-generation cytogenetics

Discover next-generation cytogenetics with high-resolution optical genome mapping technology and identify structural variants (SVs) within the human genome that can be missed by current massively parallel sequencing methods.

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You are what your microbes eat

Meet one of the most heralded researchers in the microbiome community, Patrice Cani, Professor of Physiology and Nutrition at the University of Louvain, who reveals how his work has unearthed some of the most groundbreaking discoveries in the world of gut microbes, and how they influence human pathology.

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New hope for cataract treatment

Learn how Dr. Catherine Cheng, Assistant Professor at Indiana University School of Optometry, has uncovered new roles of Eph and ephrin signaling in lens health, by elucidating the molecular mechanisms that underlie age-related eye lens defects, namely cataracts and presbyopia.

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SPECIAL FEATURE: Biopharmaceuticals

Discover the latest advancements in biopharmaceutical research and technology, including a new strategy for detecting DNA changes, characterization of monoclonal antibodies and much more.

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Live-cell analysis: from culture to assay

Discover the benefits of continuous live-cell analysis in our new application compendium eBook, looking at the interconnected cellular workflows and continuous analysis cycle of cell culture, cell-based assays and cell manipulation, plus cutting-edge technologies such as the IncuCyte® Live-Cell Analysis System from Sartorius that help to deliver smarter cell monitoring.

Download eBook >>


NEW VIDEOS: Tackling tuberculosis

Watch our two new videos on The Scientists’ Channel with Dr. Kyle Rohde, associate professor at the University of Central Florida, who discusses his in vitro studies of TB in the hope of finding the next generation of antibiotic treatments to tackle the global crisis.

Watch videos >>

Upcoming webinars not to miss

- Identifying the Unknown: Easily ID Particles in Drug Formulations
- Improving Analytical Method Performance Through Quality Risk Management and a Design of Experiments Approach


The reviews about lab technology you use

Read reviews written by other scientists around the world to help you choose the best instruments for your lab, or share your opinion to help your peers by writing your own review today. Read one of our latest reviews below by Dr. Katherine Slemmons from Children’s Hospital Los Angeles for the IncuCyte® Live-Cell Analysis System by Sartorius Group.

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Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Next Generation SequencingNext-generation sequencing (NGS), also known as whole-genome sequencing, high-throughput sequencing and massive parallel sequencing, produces and analyses thousands to millions of nucleotide sequences at once. Sequencing systems operate via varying technologies depending on the manufacturer, including sequencing by synthesis, ligation, pyrosequencing, ion semiconductor and single-molecule real-time sequencing. For NGS, library preparation is paramount to successful sequencing. In this section, explore a range of library preparation kits, from targeted, amplicon-based or hybridization-based kits including epigenomic, transcriptomic and genomic workflows to fragmentation kits. Find the best next-generation sequencing products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.TuberculosisBiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.Drug DiscoveryDrug discovery is the process of identifying potential new medications, involving stages such as target identification, compound screening, and preclinical development. It relies on cutting-edge technologies like high-throughput screening, artificial intelligence, and molecular modeling to accelerate the identification of drug candidates. Drug discovery plays a pivotal role in developing new therapies for diseases ranging from cancer to rare genetic disorders. Browse our peer-reviewed product directory to find the latest drug discovery technologies, compare options, check customer feedback, and get pricing directly from manufacturers.MicrobiomeMicrobiome research focuses on the complex communities of microorganisms living in and on humans, animals, plants, and environments. It plays a crucial role in health, disease, and ecological balance. Explore tools and resources for microbiome analysis, including sequencing platforms and bioinformatics software.Cell Based AssaysCell-based assays use living cells to measure biological responses to various treatments or stimuli. They are essential for drug discovery, toxicology testing, and understanding cellular mechanisms. These assays are used to assess cell viability, proliferation, gene expression, and other cellular activities. Browse our peer-reviewed product directory to find the best cell-based assay tools and reagents, compare products, read customer reviews, and get pricing directly from manufacturers.Drug DevelopmentDrug development refers to the process of bringing a new drug to market.Cell CultureCell culture involves growing cells under controlled conditions, typically outside of their natural environment, to study cellular behavior, drug response, and disease models. Cell culture is crucial in biotechnology and biomedical research. Explore cell culture products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

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