Top Clinical News from June 2016

News highlights from the SelectScience® clinical community

14 Jul 2016
Sonia Nicholas
Managing Editor and Clinical Lead

Editorial article

Visit SelectScience® daily for the very latest clinical industry, product and research news
Image: Shutterstock/angellodeco

This article includes a selection of the most interesting clinical news from the last month. Learn about a new consortium of lung cancer experts working on next-generation sequencing; read an interview on the very latest technology available for mass spectrometry sample preparation; and find out about a ground-breaking Myeloma study in Birmingham, UK.

1. QIAGEN forms Lung Cancer Expert Alliance

QIAGEN has announced the formation of a global consortium of international lung cancer experts. The experts will advise the company on the design of new next-generation sequencing (NGS) gene panels and associated workflows that target lung cancer-specific mutations.

2. Modern Sample Preparation Solutions Bring Mass Spec to the Clinical Research Lab

Nicholas Manicke is a mass spectrometry expert and Professor of Chemistry at the Indiana University-Purdue University Indianapolis (IUPUI), U.S. In this interview with SelectScience’s Associate Editor, Sonia Nicholas, Nicholas discusses the very latest, state-of-the-art technology available for mass spectrometry sample preparation.

3. Mobile Phones Used by Hospital Staff Harbor Pathogenic Viruses

In clinical settings, mobile phones benefit patients by placing useful data and information at the fingertips of health professionals during interactions on the ward. But are doctors and nurses unwittingly exposing vulnerable patients to a potential source of infection just by tapping their touch screen?

4. Unsafe Lead Levels in Children, Finds New Study in Journal of Pediatrics

Despite four decades of public health efforts to minimize children's exposure to lead, high percentages of unsafe blood lead levels are still found in children in numerous regions of the United States, according to a new study by researchers at Quest Diagnostics, a leading provider of diagnostic information services.

5. First Large-Scale Screening Trial to Identify Blood Cancer Before Disease Develops

The Binding Site has welcomed Dr Sigurdur Kristinsson, from the University of Iceland, to its head office in Birmingham, UK to progress a landmark, large-scale screening study aimed at preventing Myeloma before it develops. The ground-breaking study will test blood samples from adults over the age of 40 in Iceland, almost one third of the country’s population, for the earliest signs of Myeloma.

6. New Case Study Shows Increased Efficiency and Faster Viral Load Results with DxN VERIS Molecular Diagnostics System

A newly released case study describes the experiences of Niguarda Hospital’s Molecular Biology Laboratory, in the assessment of the DxN VERIS Molecular Diagnostics System. The study showed that the DxN VERIS increased laboratory efficiency and allowed faster turnaround of viral load results.

Links

Tags

Blood TransfusionBlood Transfusion involves giving donor blood to a recipient patient. Screening is essential to avoid transfusion reactions. Blood banks use immunohematological techniques to determine rh and ABO blood group, and screen for antibodies using specific antisera. Blood Banks use Direct Coombs Tests (DCT) and Indirect Coombs Tests (IAT) to detect hemolysis and Haemolytic Disease of the Newborn (HDN).HematologyIn Haematology / Hematology, complete blood cell counts (or full blood counts) are obtained using automated blood count analyzers to enumerate blood cell types.  Hematology also encompasses haemostasis and coagulation, thrombophilia and hemophilia, plasma viscosity and ESR analysis, hemoglobinopathies, cell morphology and haematinic measurement.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Cellular PathologyCellular Pathology deals with the microscopic analysis of tissue samples and cells. Sample preparation and processing includes fixation, staining, sectioning and slide mounting, using equipment such microtomes and cryostats. In choosing immunohistochemistry and immunocytochemistry kits, consider chromogens, staining method, antibodies, microscopes and imaging.Point-of-CarePoint-of-Care Testing (POCT) or Near Patient Testing (NPT) products are available for urine, blood and other clinical chemistry analyses. POCT includes: blood glucose testing, blood gas and electrolytes analysis, rapid coagulation testing (PT / INR), rapid cardiac markers diagnostics, drugs of abuse screening, urine strips testing, pregnancy testing, fecal occult blood analysis, food pathogens screening, hemoglobin diagnostics, infectious disease testing and cholesterol screening.Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.Clinical MicrobiologyMicrobiology is the study of microorganisms including protists, prokaryotes, fungi, and, often, viruses. Microorganisms are a useful research tool as genetic vectors and, in immunology, for antibiotic susceptibility testing, cellular biology and genetics. Microorganisms commonly grow readily in incubators with microbial culture media; this can contain chromogenic supplements to differentiate between cell lines. Estimate your culture’s density of microorganisms with colony counters, or screen and select colonies for desirable clones with automated colony pickers. Additionally, equipment is available to monitor environments for the presence of microbes and identify with microbial identification instruments. Find the best microbiology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Clinical NGSNext Generation Sequencing (NGS) refers to the use of massive parallel sequencing of multiple small fragments of DNA. This high-throughput genomic analysis yields enormous amounts of sequence data, which if appropriately analyzed could have huge potential for clinical laboratories. For this to happen there are technique and bioinformatic hurdles to be overcome.Clinical Mass SpectrometryMass spectrometry is emerging as a superior method of analysis over the longstanding, gold standard of immunoassay. Clinical mass spectrometry systems are increasingly accessible to medical laboratories and are capable of providing results with more speed and less expense than traditional methods. From simple mass spectrometers to IVDR class A compliant, highly sophisticated systems performing liquid chromatography tandem mass spectrometry (LC/MS/MS), find the latest product news, reviews and resources to make a purchasing decision for your laboratory. Myeloma
Top Clinical News from June 2016