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Top 10 Mass Spectrometry Downloads for Clinical Scientists

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Discover the application notes, scientific posters and compendiums being downloaded daily by clinical scientists

26 Sept 2017
Sonia Nicholas
Managing Editor and Clinical Lead

Editorial article

Smith-Chetanachan © 123rf.com


More and more clinical laboratories are adopting mass spectrometry into their everyday workflow. Clinical mass spectrometry has applications in fields such as toxicology, drug monitoring, microbial identification and biomarker identification. In this article, find the top 10 clinical mass spectrometry downloads. Find more downloads, expert interviews and videos by visiting our Clinical Mass Spectrometry Special Feature.

1. A Novel Platform of Online Sample Pre-treatment and LC/MS/MS Analysis for Screening and Quantitation of Illicit Drugs in Urine

This poster describes a fully automated method of sample pretreatment and quantitation for 18 illicit drugs in human urine that was developed on a novel platform, the CLAM-2000 Automated Sample Prep Module for LC/MS/MS. The method performance was evaluated on the linearity, accuracy, specificity and process efficiency.
2. Quantitative Analysis of Vitamin D Metabolites in Plasma Using the TSQ Quantiva™ Triple-Stage Quadrupole MS

Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) has become increasingly popular method for the analysis of vitamin D metabolites in plasma. This application note details a study which evaluated the use of KM1000 kit from Immundiagnostik AG for the quantification of vitamin D metabolites in human plasma on a Thermo Scientific™ TSQ Quantiva™ triple quadrupole mass spectrometer. It found that the TSQ Quantiva mass spectrometer was a valuable and sensitive analytical tool to support vitamin D research.

3. LC-MS/MS for In Vitro Diagnostics

Liquid chromatography-tandem quadrupole mass spectrometry is swiftly becoming the technique of choice for clinical laboratory analyses. Discover the IVD medical devices that offer clinical laboratories an alternative to research use only LC-MS/MS systems. These systems are specifically designed to meet the demands of clinical laboratories and are approved for diagnostic use.

4. Rapid Detection of Necrosis in Breast Cancer with Desorption ElectroSpray Ionization Mass Spectrometry

This poster highlights how mass spectrometric analysis of ex vivo tissue slices from metastatic murine xenograft tumors from LM2-4 cell line with Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) allowed direct comparisons with histology images to determine the molecular profile of necrotic tissues. Showcasing that mass spectrometry is an ideal novel tool for rapid pathology and is highly complementary to current histology based methods widely used in characterization of cancer.

5. The Clinical Application Notebook

Download this free notebook containing 29 application notes on steroids and hormones; therapeutic drug monitoring; pain management drugs/vitamin testing and drugs of abuse.

6. MultiQuant™ Software Version 3.0 for Accurate Quantification of Clinical Research and Forensic Samples

To address the needs of modern Clinical Research and Forensic Toxicology laboratories, MultiQuant™ software version 3.0 has been designed with the goal of improving data processing efficiency, thereby accelerating the process of data review. Integrated within Analyst® software, MultiQuant™ 3.0 software enables the identification and quantification of chemicals of interest in complex samples from data files generated on AB SCIEX triple quadrupole, QTRAP®, and TripleTOF® systems.

7. Upgrading To ICP-MS from GF-AA

This article highlights some key questions asked when upgrading from Graphite Furnace Atomic Absorption (GF-AA) to Inductively Coupled Plasma – Mass Spectrometry (ICP-MS). Including benefits, cost considerations and installation questions.

8. The Role of Inductively Coupled Plasma – Mass Spectrometry (ICP-MS) in Clinical Research and Sports Doping Applications

This white paper demonstrates the power of ICP-MS for the analysis of different elements in biological matrices and demonstrates the use of trace elemental analysis in clinical research and sports doping applications.

9. Preparing Biological Samples for Elemental Analysis by ICP-MS

This study discusses the comparison of three sample preparation techniques for the analysis of biological samples, esp. whole blood, by Inductively Coupled Plasma – Mass Spectrometry (ICP-MS). The study also evaluates the effectiveness of nitrogen gas addition to plasma samples, prior to analysis.

10. Orbitrap Quantitation: Lab Of The Future

Download this comprehensive review of Thermo Fisher Scientific’s Quadrupole-Orbitrap mass spectrometer technology. Learn about the technology and its many different applications, and find related application notes.

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.Clinical Mass SpectrometryMass spectrometry is emerging as a superior method of analysis over the longstanding, gold standard of immunoassay. Clinical mass spectrometry systems are increasingly accessible to medical laboratories and are capable of providing results with more speed and less expense than traditional methods. From simple mass spectrometers to IVDR class A compliant, highly sophisticated systems performing liquid chromatography tandem mass spectrometry (LC/MS/MS), find the latest product news, reviews and resources to make a purchasing decision for your laboratory.

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