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Thermo Fisher Scientific Showcases Software Solutions for Award-Winning LTQ Orbitrap Hybrid Mass Spectrometer

Thermo Fisher Scientific
3 Mar 2007
Kerry Parker
CEO

Product news

Thermo Fisher Scientific Inc., the world leader in serving science, announced the introduction of application-specific software that unleashes the full potential of the Thermo Scientific LTQ Orbitrap™, winner of the 2006 R&D 100 award and the Editors Gold Award at PITTCON 2006. Based on the fast and highly sensitive Thermo Scientific LTQ XL™ linear ion trap, the LTQ Orbitrap hybrid mass spectrometer identifies more proteins with greater confidence than any other mass spectrometry (MS) system. The LTQ Orbitrap and software solutions will be displayed at Thermo Scientific booth #1437 at PITTCON 2007, being held February 26 to March 2 in Chicago, Illinois.

The high-quality data generated by the LTQ Orbitrap reduces false-positive rates (FPRs) compared with results obtained from other hybrids. To make the most of this high-quality data, Thermo Scientific software leverages the accurate mass capabilities of the LTQ Orbitrap to achieve the following advantages for proteomics and pharmaceutical users:

• Differential expression analysis: New SIEVE™ differential expression software provides label-free semi-quantitative differential expression analysis of proteins and peptides from the comparison of multiple LC/MS data sets. BioWorks™ software utilizes accurate mass data from the analysis of iTRAQ™-labeled peptides and the analysis of other labeling experiments such as SILAC™.

• de novo sequence analysis: PEAKS™ software makes full use of the LTQ Orbitrap’s accurate mass for definitive de novo sequencing. Featuring rapid automatic or manual de novo sequencing, PEAKS works seamlessly with Thermo Scientific Xcalibur™ RAW data files or from processed data generated using BioWorks software.

• Metabolite identification: Accurate mass full scan and MS/MS data applied in combination with MetWorks™ and Mass Frontier™ software enables fast, confident metabolite identification. MetWorks automated metabolite identification software dramatically simplifies and accelerates the processing and reporting of LC/MSn analyses. The Mass Frontier mass spectral data tool offers powerful insight into compound structures with new predictive fragmentation modules. In addition, component detection algorithms and spectral tree extractions allow for the user-defined creation of databases of target compounds.

For more information on the Thermo Scientific LTQ Orbitrap and software solutions, please visit Thermo Scientific booth #1437 at PITTCON 2007. Alternatively, please call 1-800-532-4752, click 'request info' or visit the article webpage.

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Data AnalysisData analysis hardware and software is available to make data processing straight-forward yet powerful. Data software can be used for math and stats, technical graphing and image analysis. In addition, software is available for specific data analysis of electrophoresis, densitometry, ELISA and DNA sequencing.Chem / BioinformaticsCheminformatics and bioinformatics are computational techniques used in chemistry and biology, respectively, for data acquisition, processing and storage. Cheminformatics focuses on compound information, whereas bioinformatics is mainly applied to analysis and modeling of genomics, genetic and sequencing information. Hardware and software is available for data acquisition, analysis, management and storage.

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Thermo Fisher Scientific Showcases Software Solutions for Award-Winning LTQ Orbitrap Hybrid Mass Spectrometer