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Thermo Fisher Scientific Showcases New Integrated LC-MS Drug Discovery Workflow for Maximizing Sample Throughput

Thermo Fisher Scientific
3 Mar 2008
Greg Smith
Analyst / Analytical Chemist

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Thermo Fisher Scientific Inc., the world leader in serving science, today announced the integration of Thermo Scientific Aria™ LX multiplexing technology with QuickQuan™ software. The combination enables users to increase the throughput of compounds processed in high-throughput liquid chromatography-mass spectrometry (LC-MS) assays by a factor of four. This instrument accelerates the pace of drug discovery for pharmaceutical companies, streamlining the workflow by maximizing the productivity of a single MS detector. The complete system will be showcased at the Thermo Scientific booth 1741 at PITTCON 2008, being held March 3–6 in New Orleans.

The unique Thermo Scientific multiplexing technology is the only truly independent, parallel, multichannel system in the industry, bringing the productivity of up to four separate LC systems to a single MS. The Thermo Scientific TSQ Quantum™ triple quadrupole mass spectrometer and an Aria LX-4 System can process as many samples as four standalone LC-MS/MS systems. The multiplexed system ensures maximum performance of the MS so the user can boost productivity without compromising data quality or sensitivity.

For laboratories that perform high-throughput screening, this integrated solution allows scientists to quickly assess thousands of new chemical entity samples in drug discovery research. QuickQuan software performs automated optimization of MS/MS parameters, enabling the rapid analysis of compounds. Data generated from QuickQuan can be seamlessly transferred to the Thermo Scientific Galileo LIMS™ or QuickCalc™ software powered by Gubbs Inc. GMSU.

“The integration of these innovative Thermo Scientific products into a single solution demonstrates Thermo Fisher’s commitment to developing technologies for our customers that simplify their processes and improve laboratory productivity,” said Dr. Ian Jardine, vice president of global research and development for Thermo Fisher Scientific. “As the leader in mass spectrometry, we have an unmatched portfolio that enables us to develop sophisticated, yet intuitive, workflows for our customers.”

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Data AnalysisData analysis hardware and software is available to make data processing straight-forward yet powerful. Data software can be used for math and stats, technical graphing and image analysis. In addition, software is available for specific data analysis of electrophoresis, densitometry, ELISA and DNA sequencing.

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Thermo Fisher Scientific Showcases New Integrated LC-MS Drug Discovery Workflow for Maximizing Sample Throughput