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Thermo Fisher Scientific Partners with Phytronix Technologies to Offer Ultra High-Speed LDTD Technology for Large Volume LC/MS Analyses

Thermo Fisher Scientific
12 Nov 2007
Greg Smith
Analyst / Analytical Chemist

Product news

Thermo Fisher Scientific Inc., the world leader in serving science, announces a strategic partnership with Phytronix Technologies, a Canada-based company, for the use of Laser Diode Thermal Desorption (LDTD) technology. LDTD™ technology enhances the existing Thermo Scientific TSQ Quantum™ LC/MS product portfolio by offering ultra fast sample analysis for both quantitative and qualitative applications in high-throughput drug discovery, drug development, food safety and environmental applications.

This unique technology, consisting of a semi-conductor based laser diode, allows scientists to rapidly analyze compounds. The workflow is enhanced by simply loading the Phytronix Lazwell™ 96-well plate with the sample, and inserting the plate into the LDTD ion source operating at atmospheric pressure. The LDTD technology increases the speed of analysis of compounds by 20 to 100 times compared to established techniques based on liquid chromatography with mass spectrometry. Pharmacokinetic studies using LDTD technology can be performed in less than 10 minutes, and enzyme inhibition assays in 18 minutes – compared to 10 hours presently required with LC-MS techniques.

The LDTD™ ion source utilizes an infrared laser diode to thermally desorb the dried sample. The desorbed sample is transferred in the APCI region where it is ionized and then transferred into the MS. When configured with the TSQ Quantum, the system delivers fast and efficient quantitative and qualitative results. Applications include the analysis of sulfonamide residues in milk, analysis of explosives such as HMX, RDX, and TNT, and analysis of fatty acids in both positive and negative ion mode. One unique advantage of this technology is that it can be used in mobile units for real-time, on-location environmental testing as seen in the operation of an LDTD-based TSQ Quantum for air quality testing by the Québec Environmental Agency.

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.

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