Thermo Fisher Scientific Offers Unique LC-MS/MS Offering with Cohesive Technologies Acquisition

Thermo Fisher Scientific Inc., the world leader in serving science, announces the acquisition of Cohesive Technologies Inc, a manufacturer of advanced sample extraction and high performance liquid chromatography products.

TurboFlow™ technology enhances the existing Thermo Scientific liquid chromatography (LC) and mass spectrometry (MS) product portfolio by minimizing sample preparation in LC, especially for drug discovery, drug development and clinical research applications.

This unique solution allows scientists to reduce matrix effects during pre-clinical bioanalysis, making it easier to comply with the FDA/CDER Bioanalytical Method Validation Guidance that states that “In the case of LC-MS-MS-based procedures, appropriate steps should be taken to ensure the lack of matrix effects throughout the application of the method, especially if the nature of the matrix changes from the matrix used during method validation.”

The TurboFlow™ technology works by retaining small molecules, filtering out proteins and larger materials by diffusion, size exclusion and column chemistry. This enables users to directly inject biological samples into the LC-MS/MS system prior to analysis, a significant advantage in pre-clinical bioanalysis, where extensive sample preparation is too time-consuming due to the high sample loads. TurboFlow™ technology can be coupled with the Thermo Scientific TSQ Quantum™ triple quadrupole mass spectrometer combined with FAIMS (High-Field Asymmetric Ion Mobility Mass Spectrometry) to achieve a unique LC-MS/MS solution. When configured to the TSQ Quantum, the system delivers fast and efficient quantitative results with the lowest ion suppression and chemical noise, resulting in highly sensitive bioanalytical methods, development of more robust methods, and reduction in analysis failures.