Thermo Fisher Scientific Introduces New Integrated Liquid Handling Option for HCS

6 Apr 2008
Greg Smith
Analyst / Analytical Chemist

Product news

Thermo Fisher Scientific Inc., the world leader in serving science has today introduced the new Thermo Scientific Liquid Handling Module for the ArrayScan VTI HCS Reader. Synchronous dispense-while-imaging capability, combined with kinetic image capture, a market-leading range of image analysis algorithms, and “on the fly” processing, allow the real-time capture of cellular phenotypes and rapid biological responses. Furthermore, multiple aspirate/dispense options enable dye loading, media replacement, incubation and stimulus addition to be fully automated. The Thermo Scientific Cellomics ArrayScan VTI with Liquid Handling Module provides a best-in-class automated solution for pharmacological studies, including GPCR biology, cell pathway analysis, compound pharmacology and In Vitro toxicology.

Ready-to-go, the Thermo Scientific Liquid Handling Module is fully compatible with all ArrayScan VTI models. Seamless integration with the ArrayScan software provides full use of industry leading functionality such as intelligent acQuisition, multiple protocols and automated plate-handling. All functions are easy-to-use and multiple aspirate, dispensing and mixing are available from four deck locations for simple and highly flexible experimental set up. The Liquid Handling Module is also capable of single tip aspirate to any location. Compatible with 96 and 384 well plates, the module utilizes disposable tips with a dispense volume range of 3 – 200 µL, and an optional disposable tip wash, reducing the risk of cross contamination. Furthermore, pipetting will not interfere with screening or multiple operator use.

The Liquid Handling Module joins a host of popular modular options designed to further increase the flexibility and functionality of the ArrayScan VTI HCS Reader Platform. Also available is the Live Cell Chamber, the Brightfield module, a range of optional objectives, the CataLyst Express Plate Handling Robot and the ApoTome.

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Lab-on-a-ChipLab-on-a-chip (LOC) technology uses microfluidic chips, such as microarrays, to perform biochemical assays on a small scale. Benefits of lab-on-a-chip include the small volume of sample required as well as the speed of analysis. In selecting lab-on-a-chip devices consider the assay, cost, reliability, sensitivity and signal to noise ratio.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.
Thermo Fisher Scientific Introduces New Integrated Liquid Handling Option for HCS