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Thermo Fisher Scientific Introduces Automated Genotoxicity Assessment

1 Mar 2012

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Thermo Fisher Scientific Inc., a world leader in serving science, today introduced the Thermo Scientific ToxInsight Genotoxicity Panel, a revolutionary method for examining mutagenic potential of industrial and consumer chemicals.

In July of 2010, the Organization of Economic Cooperation and Development (OECD) passed test guideline 487 as the only international standard test method for assessing micronucleus formation in response to mutagenic chemicals, a test required by chemical safety legislation. Manual operation of the test requires days to complete for a single chemical.

In response, Thermo Fisher Scientific announced today the launch of a fully enabled Micronucleus Test Platform compliant with the OECD guideline. The technology combines the Thermo Scientific ToxInsight CHPS Platform with reagent cartridges and validated standard operating procedure to reduce the time per test to a small fraction of the conventional manual procedure.

In addition, the ToxInsight CHPS Platform is supplemented with automated procedures for analyzing comet formation in cells in conjunction with numerous commercially available comet preparation products. This adds a mutagenicity research tool cells to the Genotoxicity Panel for use on non-dividing cells.

The ToxInsight CHPS Platform makes multiple measurements on each cell, generating a phenotype rather than a single measurement as compared to traditional biochemical assays (such as cell count, LDH, MTT etc.). In addition to automated Genotoxicity Assessment, this automated, bench-top platform is easy-to-use and provides physiologically relevant toxicity assays in vitro, reducing the reliance on late-stage histopathology or animal studies. The ToxInsight CHPS Platform not only profiles compounds for their toxicity risk, but it also determines the mechanism of action of any toxicity detected enabling researchers to rapidly understand the risk of an endocrine active chemical in minutes.

The Genotoxicity Panel and ToxInsight CHPS Platform will be exclusively demonstrated at booth 1634 at the meeting of the Society of Toxicology 2012 annual meeting, San Francisco, California, March 12-14, 2012.

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Medicinal ChemistryMedicinal chemistry is a broad discipline encompassing the design, identification, synthesis and development of chemicals in drug discovery. It includes a number of techniques covering structural biology, synthetic chemistry and molecular biology. Technologies used in medicinal chemistry include ADME, lab-on-a-chip, high content screening and assay assembly.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Clinical TrialsClinical Trials, an essential part of drug discovery process, assess the safety and effectiveness of a new medication or device in the pharmaceutical industry. Clinical Trials are a phased process (Phase 0, Phase I, Phase II, Phase III and Phase IV) which begins after initial preclinical testing.Toxicology / Drugs of Abuse TestingToxicology and Drugs of Abuse Testing is the investigation into toxic and illegal substances found at the scene of a crime or from a suspect and / or victim associated with a scene of a crime. Analyzers, immunoassays and drugs of abuse test kits and presumptive test kits are an essential aspect of toxicology investigation.GenotoxicityMutagenesis

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Thermo Fisher Scientific Introduces Automated Genotoxicity Assessment