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Thermo Fisher Scientific Collaboration to Focus on Advancing LC-MS Techniques for Protein Analysis

Thermo Fisher Scientific
25 Jan 2013

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Thermo Fisher Scientific Inc., the world leader in serving science, has entered into a Technology Alliance Partnership agreement with scientists at the Barnett Institute, Northeastern University, Boston, MA. This partnership establishes a formal collaboration to accelerate research in high-resolution accurate mass liquid chromatography-mass spectrometry (LC-MS) applications.

The agreement, a broad collaboration between Thermo Fisher scientists and Northeastern scientists will include: performing research and sharing samples and data that could lead to development of improved techniques, exchanging ideas and opinions about improving instrument and software performance, discourse about current technology issues and publishing new methodologies and scientific advances.

The alliance, with the Barnett Institute’s Director Barry Karger and team, will focus on three research areas:
• Comprehensive characterization of complex proteins
• Ultra-trace analysis methodologies of proteomic samples
• New LCMS based methods for analysis of biosimilars

“Academic research labs are tremendous sources of innovation, which is why we’re so pleased to collaborate with Northeastern scientists who have particular expertise in combining the strengths of separation science and high resolution MS analysis of proteins,” said Iain Mylchreest, vice president, Research and Development, Thermo Fisher.

“This agreement formalizes our commitment to actively expedite the development and application of important new technologies,” said Professor Karger. “We are very pleased to strengthen the ongoing collaboration of our laboratory with Thermo Fisher in LC-MS protein analysis for biomedical and biotechnology applications.”

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. 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Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiosimilarsBiosimilars are very similar versions of approved and authorized medicines. 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