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Thermo Fisher Scientific and 908 Devices Demonstrate Innovative Separation Technology with Industry-Leading Orbitrap Mass Spectrometers at ASMS 2016

Thermo Fisher Scientific

New innovative ZipChip microfluidic inlet technology designed for fast MS analysis of biomolecules

23 Jun 2016
Weylan Kiam-Laine
Microbiologist

Product news

Thermo Fisher Scientific Inc., the world leader in serving science, and 908 Devices, a pioneer of purpose-built analytical devices for chemical analysis, demonstrated the combination of 908 Devices’ new ZipChip microfluidics separation technology with Thermo Fisher’s mass spectrometers, delivering high-quality separations that transform MS analysis of biomolecules.

Customers using the Thermo Scientific Exactive series, Thermo Scientific Q Exactive series and Thermo Scientific LTQ Orbitrap Hybrid FT mass spectrometers will be able to incorporate 908 Devices’ new ZipChip™ to enhance their analytical capabilities.

“Our customers, particularly in biopharma, have an increasing need for both small molecule and intact protein analysis and seek new separation solutions to speed overall analysis time,” said Iain Mylchreest, vice president, research and development, chromatography and mass spectrometry at Thermo Fisher. “ZipChip provides a new and innovative inlet technology that provides fast, high resolution separations of biomolecules for MS analysis in biopharma characterization workflows.”

ZipChip uses integrated microfluidics to separate biological samples in three minutes or less prior to MS characterization, and requires only a few nanoliters of sample. Users can select between two chip types—ZipChip HS for small molecule analysis and peptide mapping or ZipChip HR for intact large molecules. With this new inlet technology option, Thermo Fisher customers can take advantage of fast, integrated separation and characterization of complex biomolecules using the combination of microfluidic capillary electrophoresis (CE) and HRAM MS techniques to accelerate the pace and productivity of the biopharmaceutical and biotech development process.

"Our biopharmaceutical partners are calling ZipChip a 'game changer.' Its ability to separate intact proteins and antibodies, while giving a full mass spectrum for every peak, promises benefit throughout drug development and manufacturing,” said Dr. Chris Petty, co-founder & VP of Business Development, 908 Devices. “We are excited to be working with Thermo Fisher, a clear leader in mass spectrometry, to enhance customer capabilities and for our first ZipChip interface to be Thermo Fisher compatible.”

To find out more about 908 Devices, click here.

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Capillary ElectrophoresisCapillary electrophoresis (CE) is used to separate molecules based on charge, size and hydrophobicity. Pressure, voltage or a vacuum is used to introduce the sample to fused silica capillaries. Fluorescence, UV/Vis, UV or diode array detectors are used to visualize components. Types of CE systems include capillary electrochromatography (CEC), capillary zone electrophoresis and capillary gel electrophoresis. Find the best capillary electrophoresis equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Bioprocessing / FermentationBioprocessing is the use of biological materials to perform commercial, scientific or medical research processes. Biological materials used include cells, enzymes and organisms. Usually bioprocessing requires a batch or continuous bioreactor such as a fermentor or cell culture system. The advantages of using a reactor include high productivity, easy configuration, adjustable values and automation.Protein BiologyThe analysis of protein expression, identity and function is vital for many areas of life science research and drug discovery. Some of the most commonly used techniques in protein analysis include Western blotting, electrophoresis and mass spectrometry.MicrofluidicsMicrofluidics is the science of manipulating small volumes of fluids in micro-sized channels. It is widely used in diagnostics, drug development, and lab-on-a-chip technologies. Microfluidic devices can enable rapid, cost-effective, and high-throughput analysis of biological samples. Browse our peer-reviewed product directory to find the best microfluidic devices, compare products, check reviews, and get pricing directly from manufacturers.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.ChromatographyChromatography is a powerful technique used to separate and analyze components of mixtures based on their chemical properties. It is widely used in fields like biochemistry, pharmaceuticals, and environmental analysis. By exploiting differences in the interaction of substances with a stationary phase and a mobile phase, chromatography enables precise purification and quantification of compounds. Whether you're working with complex biological samples or industrial chemicals, chromatography is essential for obtaining high-quality results. Browse our peer-reviewed product directory to find the best chromatography systems, compare products, read customer reviews, and get pricing directly from manufacturers.BiotechnologyBiotechnology is the use of biological processes, organisms, or systems in the production of products and services. It spans a wide range of applications, including healthcare, agriculture, and environmental management. Browse our peer-reviewed product directory to find the best biotechnology tools, compare products, check reviews, and get pricing directly from manufacturers.

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