SelectScience
Join Free
Accelerating Science
NewsSeparations

Thermo Fisher's new LC-MS workstream offers a comprehensive solution for toxicology

Thermo Fisher Scientific

Thermo Scientific Tox Explorer Collection provides instruments, columns and consumables with reliable and validated methods for reproducible results

5 Oct 2020
Diane Li
Assistant Editor

Product news

Clinical research, forensic and anti-doping toxicology laboratories facing the challenges of analyzing increasing numbers of analytes in biological matrices, can now easily and rapidly optimize their liquid chromatography-mass spectrometry (LC-MS) methods for targeted screening and quantification.

The new Thermo Scientific Tox Explorer Collection offers a comprehensive LC-MS workstream for toxicology assays. The Tox Explorer Collection consists of proven and tested methods enabling toxicology laboratories to achieve accurate, high-resolution data, regardless of analyte type, matrix complexities or user expertise. The Tox Explorer Collection consists of a comprehensive library of analytes, allowing for faster identification and targeted screening assays with 1,500 compounds confirmed in a single analysis.

The Thermo Scientific Tox Explorer Collection is compromised of the following components:

  • Thermo Scientific Q Exactive Plus Hybrid Quadrupole-Orbitrap mass spectrometer

  • Thermo Scientific Vanquish Flex UHPLC system

  • Thermo Scientific TraceFinder software

  • Thermo Scientific Accucore column and consumables configured for high performance

  • An extensive HRAM mzVault library of 1,500+ compounds and database with streamlined data processing and reporting

  • Proven method comprising critical hardware parameters along with a step-by-step walkthrough guide for quick start-up and method installation

  • Application support and training

“Toxicology laboratories must ensure they carry out reliable, reproducible and sensitive analyses with a quick turnaround, using numerous instruments and software to ensure thorough sample screening,” said Brad Hart, senior director, clinical research, chromatography and mass spectrometry, Thermo Fisher Scientific. “The Thermo Scientific Tox Explorer Collection provides a robust, consistent, all-in-one LC-MS workstream, with an extensive library of analytes to allow for high-performance, targeted analyte screening on a daily basis.”

Simon Hudson, technical director at LGC, said, “As a sports anti-doping testing laboratory, we look for a user-friendly and accurate means of testing samples at a high throughput, without compromising results. The Thermo Scientific Tox Explorer Collection provides us with an easy-to-implement workstream, consisting of a selection of toxicology solutions to facilitate targeted screening and quantification. We can, therefore, confidently achieve an outstanding quality of data, allowing LGC to stay competitive as an anti-doping analysis provider.”

To accompany the Tox Explorer Collection, Thermo Fisher Scientific offers a strong customer support network, comprising a comprehensive training and application support package. The package is coupled with a complete start-up guide that includes installation and method instructions. The collection also includes a complete portfolio of services and support solutions from Unity Lab Services, Thermo Fisher Scientific’s single source for integrated lab service, assistance and supply management.

For more of the latest science news, straight to your inbox, become a member of SelectScience for free today>>

Related products

Request Quote for All Products

Thermo Scientific Accucore Biphenyl LC column

Thermo Fisher Scientific

Having trouble resolving your compounds using your C18 column? The new Thermo Scientific Accucore Biphenyl LC column is your solution for: Aromatic & moderately polar analytes, Drugs of abuse, Steroids Now you can stop struggling with unresolved peaks, long run times, and poor lot-to-lot consistency. Obtain unique selectivity for aromatic and moderately polar analytes using Accucore Biphenyl LC Columns. These columns have optimized packing, offering a rugged platform for a variety of matrices.

(0)

Thermo Scientific™ Vanquish™ Flex Quaternary UHPLC System

Thermo Fisher Scientific

The Thermo Scientific™ Vanquish™ Flex Binary UHPLC system is biocompatible with a state-of-the-art binary high-pressure pump and state-of-the-art binary solvent blending. This ultra high performance liquid chromatography system shares all Vanquish values, such as a design focused on uptime, robustness and reliability. Multiple detection options as well as Thermo Scientific™ Viper™ fingertight connections throughout the system will give you the performance you need with the ease of use you want. Our SmartFlow™ pumping technology with automatic compensation for changing eluent compressibility ensures excellent flow and gradient precision, independent of eluent composition and backpressures. This gives you unrivaled retention time precision and highest data confidence, even for ternary and quaternary gradients, and for more freedom in method development and application switching. Detection capabilities include high sensitivity and linearity Diode Array Detection with LightPipe technology, selective and sensitive Fluorescence Detection and near-universal detection capabilities with the Vanquish Charged Aerosol Detector. Key Features: Integrated modularity design concept to offer uncompromising UHPLC State-of-the-art quaternary solvent blending 1000 bar of pump pressure and flow rates up to 8 mL/min Industry-leading flow and gradient precision Multiple detection options including DAD, FLD and CAD Relevant Applications: Separations of Intact mAbs Analysis of labeled glycans Ternary gradient impurity profiling Efficient, reliable peptide mapping

(14)

Links

Thermo Fisher ScientificCompany website

Tags

UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Thin Layer ChromatographyThin-layer chromatography (TLC), also called planar chromatography, is an inexpensive and simple liquid chromatographic technique used to separate and identify small amounts of compound in a mixture, monitor progress of a reaction or determine purity of substance. TLC plates come in multiple sizes with common adsorbent layers being silica, aluminum oxide or cellulose and high-performance (HP-TLC) plates are also available for increased sensitivity. Other equipment needed includes TLC developing chambers, applicators, TLC sprayers and visualizing devices, such as a viewing cabinet and UV lamp. Find the best TLC products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Toxicology / Drugs of Abuse TestingToxicology and Drugs of Abuse Testing is the investigation into toxic and illegal substances found at the scene of a crime or from a suspect and / or victim associated with a scene of a crime. Analyzers, immunoassays and drugs of abuse test kits and presumptive test kits are an essential aspect of toxicology investigation.ChromatographyChromatography is a powerful technique used to separate and analyze components of mixtures based on their chemical properties. It is widely used in fields like biochemistry, pharmaceuticals, and environmental analysis. By exploiting differences in the interaction of substances with a stationary phase and a mobile phase, chromatography enables precise purification and quantification of compounds. Whether you're working with complex biological samples or industrial chemicals, chromatography is essential for obtaining high-quality results. Browse our peer-reviewed product directory to find the best chromatography systems, compare products, read customer reviews, and get pricing directly from manufacturers.Forensic ToxicologyForensic toxicology is used to determine cause of death, drug use and contaminations. Toxicological evaluations are commonly used in analytical chemistry, clinical, life sciences and forensics.HPLCHigh-performance liquid chromatography (HPLC) is a technique for separating, identifying, and quantifying components in mixtures. It is widely used in chemical, pharmaceutical, and environmental analysis to ensure purity and identify unknown compounds. Explore the best HPLC systems in our peer-reviewed product directory; compare products, read reviews, and get pricing directly from manufacturers.LC-MSLiquid Chromatography-Mass Spectrometry (LCMS) is a powerful analytical technique that combines the separation power of liquid chromatography with the detection capabilities of mass spectrometry. It is widely used for qualitative and quantitative analysis of complex mixtures in pharmaceuticals, proteomics, and environmental studies. Browse our peer-reviewed product directory to find the best LCMS systems, compare products, check reviews, and get pricing directly from manufacturers.

Related articles