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The New DON-NIV WB Immunoaffinity Column Significantly Enhances Laboratory Analysis of Mycotoxins

Waters
1 Jul 2012

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Waters Corporation announced today that VICAM®, a Waters® Business, has introduced the DON-NIV™ WB Immunoaffinity (IA) column, which simultaneously screens for deoxynivalenol (DON) and nivalenol (NIV). Coupled with liquid chromatography analysis, the DON-NIV WB column provides over 90% recovery of both DON and NIV and doubles the productivity of commercial, government, and food safety research laboratories.

"The new DON-NIV WB column provides rapid and simple sample preparation using the superior strength of monoclonal antibody technology. DON and NIV are analyzed simultaneously in the same sample, facilitating efficient research and more effective risk management for industry," said Dr. Stephen Powers, Head of Research & Development for VICAM.

"DON was the first trichothecene mycotoxin to be regulated by many countries. Increased interest in related toxins such as NIV drives the need for improved technologies," comments Marjorie Radlo, General Manager, Director of Operations, for VICAM.

DON and NIV are trichothecene mycotoxins produced by fusarium molds. Animal feeds which are contaminated with fusarium toxins cause feed refusal, weight loss, vomiting and diarrhea – resulting in significant health, production, and economic risks. NIV has also been linked to lung and brain hemorrhage and bone marrow injury through disruption of DNA and protein synthesis.

The DON-NIV WB column meets all of the stringent European Union regulations for the recovery of DON in food and feeds which specify 0.2 ppm for infant foods, 0.5 ppm for breads, pastries, biscuits and cereals, and 1.75 ppm for wheat, oats, and maize. The US Food and Drug Administration advise no more than 1 ppm DON in wheat products intended for human consumption and specific levels for feeding of livestock animals. While there are currently no officially set detection limits for NIV, growing research on the co-occurrence of toxins and the potential for amplified toxicity is driving the need for increased awareness and potential regulation.

This product will be revealed at the MycoRed North America Conference in Ottowa, Canada on June 25, 2012. Data will be discussed at a presentation given by Dr. Michelangelo Pascale, Institute of Sciences of Food Production, National Research Council, Italy.

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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.MicrobiologyMicrobiology is the study of microorganisms including protists, prokaryotes, fungi, and, often, viruses. Microorganisms are a useful research tool as genetic vectors and, in immunology, for antibiotic susceptibility testing, cellular biology and genetics. Microorganisms commonly grow readily in incubators with microbial culture media; this can contain chromogenic supplements to differentiate between cell lines. Estimate your culture’s density of microorganisms with colony counters, or screen and select colonies for desirable clones with automated colony pickers. Additionally, equipment is available to monitor environments for the presence of microbes and identify with microbial identification instruments. Find the best microbiology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.DNA SequencingDNA sequencing, such as sanger sequencing, is a biological technique that determines the precise order of nucleotide bases in a fragment or template of DNA. DNA sequencers and genetic analyzers are based on capillary electrophoresis, where labeled DNA fragments are electrophoretically separated by size as they migrate through a polymer. Find the best DNA sequencing products, including DNA sequencing kits, genomic libraries and genetic identity kits in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Monoclonal AntibodiesMonoclonal antibodies (mAbs) are lab-made molecules that can bind to specific antigens on cells, making them highly effective in treating cancers, autoimmune diseases, and infections. These targeted therapies are transforming the treatment landscape for many conditions. Browse our peer-reviewed product directory to find monoclonal antibodies for research and clinical applications; compare products, check reviews, and get pricing directly from manufacturers.MycotoxinsToxic chemicals such as Aflatoxin and Alkaloids that are produced by fungi are known as mycotoxins. In humid conditions, fungi can proliferate and colonize on crops to levels that can be damaging to human health.

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The New DON-NIV WB Immunoaffinity Column Significantly Enhances Laboratory Analysis of Mycotoxins